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A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.

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Title: A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.
Authors: Miller BR; Department of Psychiatry, Columbia University, New York, NY 10032.; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032., Gonzaga-Jauregui C; Regeneron Genetics Center, Tarrytown, NY 10591.; International Laboratory for Human Genome Research, Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, 76230, Querétaro, Mexico., Brigatti KW; Clinic for Special Children, Gordonville, PA 17529., de Jong J; Department of Psychiatry, Columbia University, New York, NY 10032.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032., Breese RS; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Ko SY; Department of Psychiatry, Columbia University, New York, NY 10032.; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032., Puffenberger EG; Clinic for Special Children, Gordonville, PA 17529., Van Hout C; Regeneron Genetics Center, Tarrytown, NY 10591.; International Laboratory for Human Genome Research, Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, 76230, Querétaro, Mexico., Young M; Clinic for Special Children, Gordonville, PA 17529., Luna VM; Department of Neural Sciences, Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140., Staples J; Regeneron Genetics Center, Tarrytown, NY 10591., First MB; Department of Psychiatry, Columbia University, New York, NY 10032., Gregoire HJ; Department of Psychiatry, Columbia University, New York, NY 10032.; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032., Dwork AJ; Department of Psychiatry, Columbia University, New York, NY 10032., Pefanis E; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., McCarthy S; Regeneron Genetics Center, Tarrytown, NY 10591., Brydges S; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Rojas J; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Ye B; Regeneron Genetics Center, Tarrytown, NY 10591., Stahl E; Regeneron Genetics Center, Tarrytown, NY 10591., Di Gioia SA; Regeneron Genetics Center, Tarrytown, NY 10591., Hen R; Department of Psychiatry, Columbia University, New York, NY 10032.; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032., Elwood K; Geisinger Health System, Danville, PA 17822., Rosoklija G; Department of Psychiatry, Columbia University, New York, NY 10032., Li D; Regeneron Genetics Center, Tarrytown, NY 10591., Mellis S; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Carey D; Geisinger Health System, Danville, PA 17822., Croll SD; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Overton JD; Regeneron Genetics Center, Tarrytown, NY 10591., Macdonald LE; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Economides AN; Regeneron Genetics Center, Tarrytown, NY 10591.; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Shuldiner AR; Regeneron Genetics Center, Tarrytown, NY 10591., Chuhma N; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032., Rayport S; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032., Amin N; Department of Psychiatry, Erasmus University Medical Center, Rotterdam 3015 GD, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3015 GD, The Netherlands., Kushner SA; Department of Psychiatry, Columbia University, New York, NY 10032.; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032., Alessandri-Haber N; Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY 10591., Markx S; Department of Psychiatry, Columbia University, New York, NY 10032.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032., Strauss KA; Clinic for Special Children, Gordonville, PA 17529.; Department of Pediatrics, Penn Medicine-Lancaster General Hospital, Lancaster, PA 17602.; Departments of Pediatrics and Molecular, Cell and Cancer Biology, University of Massachusetts School of Medicine, Worcester, MA 01655.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Apr 22; Vol. 122 (16), pp. e2404754122. Date of Electronic Publication: 2025 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.
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