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Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling.

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Title: Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling.
Authors: Régnier M; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Polizzi A; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Fougeray T; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Fougerat A; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Perrier P; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Anderson K; The Signaling Programme, The Babraham Institute, Cambridge, United Kingdom., Lippi Y; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Smati S; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Lukowicz C; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Lasserre F; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Fouche E; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Huillet M; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Rives C; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Tramunt B; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France.; Diabetology Department, CHU de Toulouse, Toulouse, France., Naylies C; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Garcia G; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Rousseau-Bacquié E; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Bertrand-Michel J; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France.; Metatoul-Lipidomic Facility, MetaboHUB, Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France., Canlet C; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Chevolleau-Mege S; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Debrauwer L; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Heymes C; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France., Burcelin R; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France., Levade T; Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm U1037, CNRS U5071, Université de Toulouse, Toulouse, France.; Laboratoire de Biochimie, CHU de Toulouse, Toulouse, France., Gourdy P; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France.; Diabetology Department, CHU de Toulouse, Toulouse, France., Wahli W; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Center for Integrative Genomics, Université de Lausanne, Lausanne, Switzerland., Blum Y; Univ Rennes, CNRS, INSERM, IGDR (Institut de Génétique et Développement de Rennes) - UMR6290, ERL U1305, Rennes, France., Gamet-Payrastre L; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Ellero-Simatos S; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Guillermet-Guibert J; Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm U1037, CNRS U5071, Université de Toulouse, Toulouse, France., Hawkins P; The Signaling Programme, The Babraham Institute, Cambridge, United Kingdom., Stephens L; The Signaling Programme, The Babraham Institute, Cambridge, United Kingdom., Postic C; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Montagner A; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France., Loiseau N; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France., Guillou H; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.
Source: PLoS biology [PLoS Biol] 2025 Apr 14; Vol. 23 (4), pp. e3003112. Date of Electronic Publication: 2025 Apr 14 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling.
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  Data: <searchLink fieldCode="AU" term="%22Régnier+M%22">Régnier M</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.<br /><searchLink fieldCode="AU" term="%22Polizzi+A%22">Polizzi A</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Fougeray+T%22">Fougeray T</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Fougerat+A%22">Fougerat A</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Perrier+P%22">Perrier P</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Anderson+K%22">Anderson K</searchLink>; The Signaling Programme, The Babraham Institute, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lippi+Y%22">Lippi Y</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Smati+S%22">Smati S</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Lukowicz+C%22">Lukowicz C</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Lasserre+F%22">Lasserre F</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Fouche+E%22">Fouche E</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Huillet+M%22">Huillet M</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rives+C%22">Rives C</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Tramunt+B%22">Tramunt B</searchLink>; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France.; Diabetology Department, CHU de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Naylies+C%22">Naylies C</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Garcia+G%22">Garcia G</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rousseau-Bacquié+E%22">Rousseau-Bacquié E</searchLink>; 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Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Burcelin+R%22">Burcelin R</searchLink>; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Levade+T%22">Levade T</searchLink>; Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm U1037, CNRS U5071, Université de Toulouse, Toulouse, France.; Laboratoire de Biochimie, CHU de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Gourdy+P%22">Gourdy P</searchLink>; Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France.; Diabetology Department, CHU de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Wahli+W%22">Wahli W</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Center for Integrative Genomics, Université de Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Blum+Y%22">Blum Y</searchLink>; Univ Rennes, CNRS, INSERM, IGDR (Institut de Génétique et Développement de Rennes) - UMR6290, ERL U1305, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Gamet-Payrastre+L%22">Gamet-Payrastre L</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Ellero-Simatos+S%22">Ellero-Simatos S</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Guillermet-Guibert+J%22">Guillermet-Guibert J</searchLink>; Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm U1037, CNRS U5071, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Hawkins+P%22">Hawkins P</searchLink>; 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