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Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.

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Title: Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
Authors: Awalt JK; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Ooi ZK; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Ashton TD; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Mansouri M; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Calic PPS; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Zhou Q; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Vasanthan S; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Lee S; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Loi K; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Jarman KE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Penington JS; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Qiu D; Research School of Biology, Australian National University, Canberra 2601, Australia., Zhang X; Research School of Biology, Australian National University, Canberra 2601, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra 2601, Australia., Mao EY; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Gancheva MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Giannangelo C; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., MacRaild CA; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Creek DJ; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Yeo T; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY 10032, USA., Sheth T; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY 10032, USA., Fidock DA; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Churchyard A; Department of Life Sciences, Imperial College London, South Kensington SW7 2AZ, U.K., Baum J; Department of Life Sciences, Imperial College London, South Kensington SW7 2AZ, U.K.; School of Biomedical Sciences, University of New South Wales, Sydney 2031, Australia., Famodimu MT; London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Delves MJ; London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Kristan M; London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Stewart L; London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Sutherland CJ; London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Coyle R; London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.; Wellcome Sanger Institute, Wellcome Genome Campus Hinxton CB10 1SA, U.K., Jagoe H; London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus Hinxton CB10 1SA, U.K.; Wellcome Centre for Anti-Infectives Research, Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Chowdury M; School of Medicine, Deakin University, Waurn Ponds 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong 3216, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Waurn Ponds 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong 3216, Australia., Baud D; Medicines for Malaria Venture, Geneva 1215, Switzerland., Brand S; Medicines for Malaria Venture, Geneva 1215, Switzerland., Jackson PF; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla 92121, United States., Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Dans MG; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Apr 24; Vol. 68 (8), pp. 8933-8966. Date of Electronic Publication: 2025 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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