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Integrating Pulmonary and Systemic Transcriptomic Profiles to Characterize Lung Injury after Pediatric Hematopoietic Stem Cell Transplant.

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Title: Integrating Pulmonary and Systemic Transcriptomic Profiles to Characterize Lung Injury after Pediatric Hematopoietic Stem Cell Transplant.
Authors: Pearce EM; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Evans E; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Mayday MY; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Departments of Laboratory Medicine and Pathology, Yale School of Medicine, New Haven, CT, USA., Reyes G; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Simon MR; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Blum J; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Kim H; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Mu J; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Shaw PJ; The Children`s Hospital at Westmead, Westmead, NSW, Australia., Rowan CM; Indiana University, Department of Pediatrics, Division of Critical Care Medicine, Indianapolis, IN, USA., Auletta JJ; Hematology/Oncology/BMT and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, USA.; CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN, USA., Martin PL; Division of Pediatric and Cellular Therapy, Duke University Medical Center, Durham, NC, USA., Hurley C; Division of Critical Care, Department of Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, USA., Kreml EM; Department of Child Health, Division of Critical Care Medicine, University of Arizona, Phoenix, AZ, USA., Qayed M; Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA., Abdel-Azim H; Department of Pediatrics, Division of Hematology/Oncology and Transplant and Cell Therapy, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Loma Linda University School of Medicine, Cancer Center, Children Hospital and Medical Center, Loma Linda, CA, USA., Keating AK; Harvard Medical School, Boston, Massachusetts; Division of Pediatric Oncology, Department of Pediatrics, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.; Center for Cancer and Blood Disorders, Children's Hospital Colorado and University of Colorado, Aurora, CO, USA., Cuvelier GDE; CancerCare Manitoba, Manitoba Blood and Marrow Transplant Program, University of Manitoba, Winnipeg, Manitoba, Canada., Hume JR; University of Minnesota, Department of Pediatrics, Division of Critical Care Medicine, Minneapolis, MN, USA., Killinger JS; Division of Pediatric Critical Care, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Godder K; Cancer and Blood Disorders Center, Nicklaus Children's Hospital, Miami, FL, USA., Hanna R; Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Pediatric Institute, Cleveland Clinic, Cleveland, OH, USA., Duncan CN; Harvard Medical School, Boston, Massachusetts; Division of Pediatric Oncology, Department of Pediatrics, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA., Quigg TC; Pediatric Blood and Marrow Transplantation Program, Texas Transplant Institute, Methodist Children's Hospital, San Antonio, TX, USA.; Section of Pediatric BMT and Cellular Therapy, Helen DeVos Children's Hospital, Grand Rapids, MI, USA., Castillo P; University of Florida, Gainesville, UF Health Shands Children's Hospital, Gainesville, FL, USA., Lalefar NR; Division of Pediatric Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, University of California San Francisco, Oakland, CA, USA., Fitzgerald JC; Department of Anesthesiology and Critical Care, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA., Mahadeo KM; Department of Pediatrics, Division of Hematology/Oncology, MD Anderson Cancer Center, Houston, TX, USA.; Division of Pediatric and Cellular Therapy, Duke University Medical Center, Durham, NC, USA., Satwani P; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University, New York, NY, USA., Moore TB; Department of Pediatric Hematology-Oncology, Mattel Children's Hospital, University of California, Los Angeles, CA, USA., Hanisch B; Children's National Hospital, Washington, District of Columbia, USA., Abdel-Mageed A; Section of Pediatric BMT and Cellular Therapy, Helen DeVos Children's Hospital, Grand Rapids, MI, USA., Davis DB; Department of Pediatrics, Hematology/Oncology, University of Mississippi Medical Center, Jackson, MS, USA., Hudspeth MP; Adult and Pediatric Blood & Marrow Transplantation, Pediatric Hematology/Oncology, Medical University of South Carolina Children's Hospital/Hollings Cancer Center, Charleston, SC, USA., Yanik GA; Pediatric Blood and Bone Marrow Transplantation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA., Pulsipher MA; Division of Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA., Dvorak CCJL; Division of Allergy, Immunology, and Bone Marrow Transplantation, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Zinter MS; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Division of Allergy, Immunology, and Bone Marrow Transplantation, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Apr 01. Date of Electronic Publication: 2025 Apr 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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IllustrationInfo
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  Data: Integrating Pulmonary and Systemic Transcriptomic Profiles to Characterize Lung Injury after Pediatric Hematopoietic Stem Cell Transplant.
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  Data: <searchLink fieldCode="AU" term="%22Pearce+EM%22">Pearce EM</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Evans+E%22">Evans E</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mayday+MY%22">Mayday MY</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Departments of Laboratory Medicine and Pathology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Reyes+G%22">Reyes G</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Simon+MR%22">Simon MR</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blum+J%22">Blum J</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mu+J%22">Mu J</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+PJ%22">Shaw PJ</searchLink>; The Children`s Hospital at Westmead, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Rowan+CM%22">Rowan CM</searchLink>; Indiana University, Department of Pediatrics, Division of Critical Care Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Auletta+JJ%22">Auletta JJ</searchLink>; Hematology/Oncology/BMT and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, USA.; CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Martin+PL%22">Martin PL</searchLink>; Division of Pediatric and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hurley+C%22">Hurley C</searchLink>; Division of Critical Care, Department of Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kreml+EM%22">Kreml EM</searchLink>; Department of Child Health, Division of Critical Care Medicine, University of Arizona, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Qayed+M%22">Qayed M</searchLink>; Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Abdel-Azim+H%22">Abdel-Azim H</searchLink>; Department of Pediatrics, Division of Hematology/Oncology and Transplant and Cell Therapy, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Loma Linda University School of Medicine, Cancer Center, Children Hospital and Medical Center, Loma Linda, CA, USA.<br /><searchLink fieldCode="AU" term="%22Keating+AK%22">Keating AK</searchLink>; Harvard Medical School, Boston, Massachusetts; Division of Pediatric Oncology, Department of Pediatrics, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.; Center for Cancer and Blood Disorders, Children's Hospital Colorado and University of Colorado, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Cuvelier+GDE%22">Cuvelier GDE</searchLink>; CancerCare Manitoba, Manitoba Blood and Marrow Transplant Program, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Hume+JR%22">Hume JR</searchLink>; University of Minnesota, Department of Pediatrics, Division of Critical Care Medicine, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Killinger+JS%22">Killinger JS</searchLink>; Division of Pediatric Critical Care, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Godder+K%22">Godder K</searchLink>; Cancer and Blood Disorders Center, Nicklaus Children's Hospital, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hanna+R%22">Hanna R</searchLink>; Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Pediatric Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Duncan+CN%22">Duncan CN</searchLink>; Harvard Medical School, Boston, Massachusetts; Division of Pediatric Oncology, Department of Pediatrics, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Quigg+TC%22">Quigg TC</searchLink>; Pediatric Blood and Marrow Transplantation Program, Texas Transplant Institute, Methodist Children's Hospital, San Antonio, TX, USA.; Section of Pediatric BMT and Cellular Therapy, Helen DeVos Children's Hospital, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Castillo+P%22">Castillo P</searchLink>; University of Florida, Gainesville, UF Health Shands Children's Hospital, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lalefar+NR%22">Lalefar NR</searchLink>; Division of Pediatric Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, University of California San Francisco, Oakland, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+JC%22">Fitzgerald JC</searchLink>; Department of Anesthesiology and Critical Care, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mahadeo+KM%22">Mahadeo KM</searchLink>; Department of Pediatrics, Division of Hematology/Oncology, MD Anderson Cancer Center, Houston, TX, USA.; Division of Pediatric and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Satwani+P%22">Satwani P</searchLink>; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Moore+TB%22">Moore TB</searchLink>; Department of Pediatric Hematology-Oncology, Mattel Children's Hospital, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hanisch+B%22">Hanisch B</searchLink>; Children's National Hospital, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Abdel-Mageed+A%22">Abdel-Mageed A</searchLink>; Section of Pediatric BMT and Cellular Therapy, Helen DeVos Children's Hospital, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Davis+DB%22">Davis DB</searchLink>; Department of Pediatrics, Hematology/Oncology, University of Mississippi Medical Center, Jackson, MS, USA.<br /><searchLink fieldCode="AU" term="%22Hudspeth+MP%22">Hudspeth MP</searchLink>; Adult and Pediatric Blood & Marrow Transplantation, Pediatric Hematology/Oncology, Medical University of South Carolina Children's Hospital/Hollings Cancer Center, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Yanik+GA%22">Yanik GA</searchLink>; Pediatric Blood and Bone Marrow Transplantation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pulsipher+MA%22">Pulsipher MA</searchLink>; Division of Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Dvorak+CCJL%22">Dvorak CCJL</searchLink>; Division of Allergy, Immunology, and Bone Marrow Transplantation, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zinter+MS%22">Zinter MS</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Division of Allergy, Immunology, and Bone Marrow Transplantation, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
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