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Short- and long-term effects of early versus delayed treatment with ocrelizumab on cerebellar volume loss in patients with RMS and PPMS.

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Title: Short- and long-term effects of early versus delayed treatment with ocrelizumab on cerebellar volume loss in patients with RMS and PPMS.
Authors: Arnold DL; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.; Neurology and Neurosurgery, NeuroRx Research, Montreal, QC, Canada., Kolind S; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Assemlal HE; Neurology and Neurosurgery, NeuroRx Research, Montreal, QC, Canada., Bar-Or A; Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Inglese M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Kappos L; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland., Parmar K; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland.; Reha Rheinfelden, Rheinfelden, Switzerland., Sprenger T; Department of Neurology, DKD Helios Klinik Wiesbaden, Wiesbaden, Germany., Traboulsee A; Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Vavasour IM; Department of Radiology, University of British Columbia, Vancouver, BC, Canada., Wolinsky JS; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA., Bernasconi C; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Bonati U; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Magon S; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Tackenberg B; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Gaetano L; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Source: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2025 Jun; Vol. 31 (7), pp. 821-832. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Short- and long-term effects of early versus delayed treatment with ocrelizumab on cerebellar volume loss in patients with RMS and PPMS.
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  Data: <searchLink fieldCode="AU" term="%22Arnold+DL%22">Arnold DL</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.; Neurology and Neurosurgery, NeuroRx Research, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Kolind+S%22">Kolind S</searchLink>; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Assemlal+HE%22">Assemlal HE</searchLink>; Neurology and Neurosurgery, NeuroRx Research, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Bar-Or+A%22">Bar-Or A</searchLink>; Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Inglese+M%22">Inglese M</searchLink>; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Kappos+L%22">Kappos L</searchLink>; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Parmar+K%22">Parmar K</searchLink>; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland.; Reha Rheinfelden, Rheinfelden, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sprenger+T%22">Sprenger T</searchLink>; Department of Neurology, DKD Helios Klinik Wiesbaden, Wiesbaden, Germany.<br /><searchLink fieldCode="AU" term="%22Traboulsee+A%22">Traboulsee A</searchLink>; Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Vavasour+IM%22">Vavasour IM</searchLink>; Department of Radiology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Wolinsky+JS%22">Wolinsky JS</searchLink>; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bernasconi+C%22">Bernasconi C</searchLink>; F. Hoffmann-La Roche Ltd, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bonati+U%22">Bonati U</searchLink>; F. Hoffmann-La Roche Ltd, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Magon+S%22">Magon S</searchLink>; F. Hoffmann-La Roche Ltd, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tackenberg+B%22">Tackenberg B</searchLink>; F. Hoffmann-La Roche Ltd, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gaetano+L%22">Gaetano L</searchLink>; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%229509185%22">Multiple sclerosis (Houndmills, Basingstoke, England)</searchLink> [Mult Scler] 2025 Jun; Vol. 31 (7), pp. 821-832. <i>Date of Electronic Publication: </i>2025 Apr 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9509185 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-0970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213524585%22">13524585 </searchLink><i>NLM ISO Abbreviation: </i>Mult Scler <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun
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