Safety and Diagnostic Utility of Brain Biopsy and Metagenomics in Decision-Making for Patients with Inborn Errors of Immunity (IEI) and Unexplained Neurological Manifestations.

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Title: Safety and Diagnostic Utility of Brain Biopsy and Metagenomics in Decision-Making for Patients with Inborn Errors of Immunity (IEI) and Unexplained Neurological Manifestations.
Authors: Maimaris J; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK. j.maimaris@ucl.ac.uk.; University College London (UCL) Institute of Immunity and Transplantation, London, UK. j.maimaris@ucl.ac.uk., Payne J; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Roa-Bautista A; Staffordshire Children's Hospital at Royal Stoke, University Hospital of North Midlands NHS Trust, Royal Stoke University Hospital, Newcastle Road, Stoke-on-Trent, UK., Breuer J; Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Storey N; Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Morfopoulou S; Department of Infection, Immunity and Inflammation, University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Bamford A; Deparment of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., D'Arco F; Department of Neuroradiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Gilmour K; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Aquilina K; Department of Paediatric Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.; Department of Neurosciences, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Hassell J; Department of Neurosciences, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Hacohen Y; Department of Neurosciences, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Silva AHD; Department of Paediatric Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.; Department of Neurosciences, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Merve A; Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Jacques TS; Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Rao K; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK.; Department of Blood and Bone Marrow Transplantation, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Chiesa R; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK.; Department of Blood and Bone Marrow Transplantation, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Amrolia P; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK.; Department of Blood and Bone Marrow Transplantation, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Silva J; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK.; Department of Blood and Bone Marrow Transplantation, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Braggins H; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Xu-Bayford J; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Goldblatt D; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Worth A; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Booth C; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Ip W; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Qasim W; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Kusters M; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK., Kaliakatsos M; Department of Paediatric Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK., Brown JR; Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK., Elfeky R; Department of Immunology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK.
Source: Journal of clinical immunology [J Clin Immunol] 2025 Apr 16; Vol. 45 (1), pp. 86. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8102137 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2592 (Electronic) Linking ISSN: 02719142 NLM ISO Abbreviation: J Clin Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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