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Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology.

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Title: Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology.
Authors: Freeman K; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada., Zwicker A; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; Dalhousie Medicine New Brunswick, St John, New Brunswick, Canada., Fullerton JM; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Hafeman DM; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., van Haren NEM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands., Merranko J; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Goldstein BI; Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Stapp EK; Milken Institute School of Public Health, George Washington University, Washington, District of Columbia., de la Serna E; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry and Psychology, 2021 SGR 01319, Hospital Clinic of Barcelona, Barcelona, Spain., Moreno D; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Sugranyes G; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry and Psychology, 2021 SGR 01319, Hospital Clinic of Barcelona, Barcelona, Spain., Mas S; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Clinical Foundations, Universitat de Barcelona, Barcelona, Spain., Roberts G; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Randwick, New South Wales, Australia., Toma C; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.; Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Consejo Superior de Investigaciones Científicas, Madrid, Spain., Schofield PR; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Edenberg HJ; Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis., Wilcox HC; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Johns Hopkins School of Medicine, Baltimore, Maryland., McInnis MG; Department of Psychiatry, University of Michigan, Ann Arbor., Propper L; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; IWK Health Centre, Halifax, Nova Scotia, Canada., Pavlova B; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Stewart SA; Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada., Denovan-Wright EM; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada., Rouleau GA; Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada., Castro-Fornieles J; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry and Psychology, 2021 SGR 01319, Hospital Clinic of Barcelona, Barcelona, Spain.; Department of Medicine, Neurosciences Institute, University of Barcelona, Barcelona, Spain., Hillegers MHJ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands., Birmaher B; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Mitchell PB; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Randwick, New South Wales, Australia., Alda M; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Nurnberger JI; Department of Psychiatry, Indiana University School of Medicine, Indianapolis.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis., Uher R; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Source: JAMA network open [JAMA Netw Open] 2025 Apr 01; Vol. 8 (4), pp. e255331. Date of Electronic Publication: 2025 Apr 01.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology.
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  Data: <searchLink fieldCode="AU" term="%22Freeman+K%22">Freeman K</searchLink>; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Zwicker+A%22">Zwicker A</searchLink>; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; Dalhousie Medicine New Brunswick, St John, New Brunswick, Canada.<br /><searchLink fieldCode="AU" term="%22Fullerton+JM%22">Fullerton JM</searchLink>; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Hafeman+DM%22">Hafeman DM</searchLink>; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22van+Haren+NEM%22">van Haren NEM</searchLink>; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Merranko+J%22">Merranko J</searchLink>; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Goldstein+BI%22">Goldstein BI</searchLink>; Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Stapp+EK%22">Stapp EK</searchLink>; Milken Institute School of Public Health, George Washington University, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22de+la+Serna+E%22">de la Serna E</searchLink>; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry and Psychology, 2021 SGR 01319, Hospital Clinic of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno+D%22">Moreno D</searchLink>; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sugranyes+G%22">Sugranyes G</searchLink>; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry and Psychology, 2021 SGR 01319, Hospital Clinic of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Mas+S%22">Mas S</searchLink>; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Clinical Foundations, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Roberts+G%22">Roberts G</searchLink>; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Randwick, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Toma+C%22">Toma C</searchLink>; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.; Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Consejo Superior de Investigaciones Científicas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Schofield+PR%22">Schofield PR</searchLink>; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Edenberg+HJ%22">Edenberg HJ</searchLink>; Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Wilcox+HC%22">Wilcox HC</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Johns Hopkins School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22McInnis+MG%22">McInnis MG</searchLink>; Department of Psychiatry, University of Michigan, Ann Arbor.<br /><searchLink fieldCode="AU" term="%22Propper+L%22">Propper L</searchLink>; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; IWK Health Centre, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Pavlova+B%22">Pavlova B</searchLink>; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Stewart+SA%22">Stewart SA</searchLink>; Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Denovan-Wright+EM%22">Denovan-Wright EM</searchLink>; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Rouleau+GA%22">Rouleau GA</searchLink>; Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Castro-Fornieles+J%22">Castro-Fornieles J</searchLink>; Fundacio Clínic per la Recerca Biomedica, Institut d'Investigacions Biomèdiques d'August Pi i Sunye, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.; Department of Child and Adolescent Psychiatry and Psychology, 2021 SGR 01319, Hospital Clinic of Barcelona, Barcelona, Spain.; Department of Medicine, Neurosciences Institute, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hillegers+MHJ%22">Hillegers MHJ</searchLink>; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Birmaher+B%22">Birmaher B</searchLink>; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Mitchell+PB%22">Mitchell PB</searchLink>; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Randwick, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Alda+M%22">Alda M</searchLink>; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Nurnberger+JI%22">Nurnberger JI</searchLink>; Department of Psychiatry, Indiana University School of Medicine, Indianapolis.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Uher+R%22">Uher R</searchLink>; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
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