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Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase.

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Title: Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase.
Authors: Lin J; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., He R; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Qu Z; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States., Dong J; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Krabill AD; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Wu L; Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Bai Y; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Conroy LR; Department of Neuroscience, University of Kentucky, Lexington, Kentucky 40506, United States., Bruntz RC; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40506, United States., Miao Y; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Jassim BA; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Babalola B; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States., Nguele Meke FGB; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Sun R; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, United States.; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida 32610, United States.; McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, United States., Gentry MS; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, United States.; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida 32610, United States., Zhang ZY; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.; Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9220-9240. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase.
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  Data: <searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22He+R%22">He R</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Qu+Z%22">Qu Z</searchLink>; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Dong+J%22">Dong J</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Krabill+AD%22">Krabill AD</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Bai+Y%22">Bai Y</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Conroy+LR%22">Conroy LR</searchLink>; Department of Neuroscience, University of Kentucky, Lexington, Kentucky 40506, United States.<br /><searchLink fieldCode="AU" term="%22Bruntz+RC%22">Bruntz RC</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40506, United States.<br /><searchLink fieldCode="AU" term="%22Miao+Y%22">Miao Y</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Jassim+BA%22">Jassim BA</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Babalola+B%22">Babalola B</searchLink>; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Nguele+Meke+FGB%22">Nguele Meke FGB</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Sun+R%22">Sun R</searchLink>; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, United States.; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida 32610, United States.; McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, United States.<br /><searchLink fieldCode="AU" term="%22Gentry+MS%22">Gentry MS</searchLink>; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, United States.; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida 32610, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+ZY%22">Zhang ZY</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.; Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9220-9240. <i>Date of Electronic Publication: </i>2025 Apr 16.
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        Value: 10.1021/acs.jmedchem.4c02580
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        Text: English
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        StartPage: 9220
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      – TitleFull: Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase.
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              Text: 2025 May 08
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