Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase.
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| Title: | Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase. |
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| Authors: | Lin J; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., He R; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Qu Z; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States., Dong J; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Krabill AD; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Wu L; Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Bai Y; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Conroy LR; Department of Neuroscience, University of Kentucky, Lexington, Kentucky 40506, United States., Bruntz RC; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40506, United States., Miao Y; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Jassim BA; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Babalola B; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States., Nguele Meke FGB; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Sun R; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, United States.; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida 32610, United States.; McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, United States., Gentry MS; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, United States.; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida 32610, United States., Zhang ZY; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.; Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9220-9240. Date of Electronic Publication: 2025 Apr 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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