Pyrimidine synthase CAD deamidates and inactivates p53.

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Title: Pyrimidine synthase CAD deamidates and inactivates p53.
Authors: Qi Y; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital, Fudan University, Shanghai, China., Tan Z; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China., Chen H; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital, Fudan University, Shanghai, China., Xiao Z; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China., Zhang L; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital, Fudan University, Shanghai, China., Wu B; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China., Liu C; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China., Gao Y; Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Yang X; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital, Fudan University, Shanghai, China., Wu L; The Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics & Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, China., Lu L; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. lulei@fudan.edu.cn., Wang H; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital, Fudan University, Shanghai, China. wanghy@fudan.edu.cn.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. wanghy@fudan.edu.cn.; Prenatal Diagnosis Center of Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, Guangzhou, China. wanghy@fudan.edu.cn.
Source: Cell research [Cell Res] 2025 Jul; Vol. 35 (7), pp. 520-523. Date of Electronic Publication: 2025 Apr 17.
Publication Type: Letter
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1748-7838
DOI:10.1038/s41422-025-01112-9