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A phase I/IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis.

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Title: A phase I/IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis.
Authors: Vachhani P; Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham., Tan P; One Clinical Research Pty Ltd, Nedlands., Watson AM; Liverpool Hospital SW Area Pathology Service, Liverpool., Wu SJ; National Taiwan University Hospital and National Taiwan University College of Medicine., Baker R; Perth Blood Institute, Murdoch University, Perth., Cheung S; ICON Cancer Care, Kurralta Park., Lee SE; The Catholic University of Korea, College of Medicine, Seoul., Chen CC; Chang-Gung Memorial Hospital, Chiayi., Chen TY; College of Medicine, National Cheng Kung University, Tainan., Hsiao HH; Kaohsiung Medical University, Kaohsiung., Lee JH; Gachon University Gil Hospital, Incheon., Masarova L; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston., Tan SY; Department of Haematology, St Vincent's Hospital, Melbourne., Baskar J; Syntara Limited, Frenchs Forest. jana.baskar@syntaratx.com.au., Charlton B; Syntara Limited, Frenchs Forest., Findlay A; Syntara Limited, Frenchs Forest., Hamprecht D; Syntara Limited, Frenchs Forest., Jarolimek W; Syntara Limited, Frenchs Forest., Leadbetter J; Syntara Limited, Frenchs Forest., Miller J; Syntara Limited, Frenchs Forest., Morgan K; Syntara Limited, Frenchs Forest., Zahoor A; Syntara Limited, Frenchs Forest., Hobbs G; Massachusetts General Hospital, Boston.
Source: Haematologica [Haematologica] 2025 Oct 01; Vol. 110 (10), pp. 2376-2387. Date of Electronic Publication: 2025 Apr 17.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A phase I/IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Vachhani+P%22">Vachhani P</searchLink>; Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; One Clinical Research Pty Ltd, Nedlands.<br /><searchLink fieldCode="AU" term="%22Watson+AM%22">Watson AM</searchLink>; Liverpool Hospital SW Area Pathology Service, Liverpool.<br /><searchLink fieldCode="AU" term="%22Wu+SJ%22">Wu SJ</searchLink>; National Taiwan University Hospital and National Taiwan University College of Medicine.<br /><searchLink fieldCode="AU" term="%22Baker+R%22">Baker R</searchLink>; Perth Blood Institute, Murdoch University, Perth.<br /><searchLink fieldCode="AU" term="%22Cheung+S%22">Cheung S</searchLink>; ICON Cancer Care, Kurralta Park.<br /><searchLink fieldCode="AU" term="%22Lee+SE%22">Lee SE</searchLink>; The Catholic University of Korea, College of Medicine, Seoul.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Chang-Gung Memorial Hospital, Chiayi.<br /><searchLink fieldCode="AU" term="%22Chen+TY%22">Chen TY</searchLink>; College of Medicine, National Cheng Kung University, Tainan.<br /><searchLink fieldCode="AU" term="%22Hsiao+HH%22">Hsiao HH</searchLink>; Kaohsiung Medical University, Kaohsiung.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Gachon University Gil Hospital, Incheon.<br /><searchLink fieldCode="AU" term="%22Masarova+L%22">Masarova L</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston.<br /><searchLink fieldCode="AU" term="%22Tan+SY%22">Tan SY</searchLink>; Department of Haematology, St Vincent's Hospital, Melbourne.<br /><searchLink fieldCode="AU" term="%22Baskar+J%22">Baskar J</searchLink>; Syntara Limited, Frenchs Forest. jana.baskar@syntaratx.com.au.<br /><searchLink fieldCode="AU" term="%22Charlton+B%22">Charlton B</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Findlay+A%22">Findlay A</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Hamprecht+D%22">Hamprecht D</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Jarolimek+W%22">Jarolimek W</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Leadbetter+J%22">Leadbetter J</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Miller+J%22">Miller J</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Morgan+K%22">Morgan K</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Zahoor+A%22">Zahoor A</searchLink>; Syntara Limited, Frenchs Forest.<br /><searchLink fieldCode="AU" term="%22Hobbs+G%22">Hobbs G</searchLink>; Massachusetts General Hospital, Boston.
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  Data: <searchLink fieldCode="JN" term="%220417435%22">Haematologica</searchLink> [Haematologica] 2025 Oct 01; Vol. 110 (10), pp. 2376-2387. <i>Date of Electronic Publication: </i>2025 Apr 17.
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  Data: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE
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        Value: 10.3324/haematol.2024.287231
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        Text: English
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              Text: 2025 Oct 01
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