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Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants.

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Title: Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants.
Authors: Lakhrif Z; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Poupée-Beaugé A; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Boursin F; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Ducournau C; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Lantier L; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Moiré N; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Carpentier R; Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France., Rossignol C; INRAe, Université de Tours, ISP, Nouzilly, France., Maquart M; MAVIVH, INSERM U1259, Université de Tours, Tours, France., Jospin F; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, Université de Lyon, Inserm, Université Claude Bernard, ENS Lyon, France.; Immunology Laboratory, Reference Center 21 iBioThera, CHU Saint-Étienne, Saint-Étienne, France., Merat L; INRAE, UE-1277 Plateforme d'Infectiologie Expérimentale (PFIE), Centre de Recherche Val de Loire, Nouzilly, France., Caul-Futy M; Epithelix Sarl, 18 Chemin des Aulx, Plan-les-Ouates, Geneva, Switzerland., Yazdanpanah Y; ANRS|Emerging Infectious Diseases/Inserm, Paris, France. Service de Maladies Infectieuses et Tropicales, Hôpital Bichat, AP-HP, Paris, France., Bouakane A; ANRS|Emerging Infectious Diseases/Inserm, Paris, France., Riou M; INRAE, UE-1277 Plateforme d'Infectiologie Expérimentale (PFIE), Centre de Recherche Val de Loire, Nouzilly, France., Touzé A; Biologie des infections à Polyomavirus team, UMR ISP1282 INRAe-Université, Tours, France., Eléouët JF; Unité de Virologie et Immunologie Moléculaires, INRAe, Université Paris Saclay, Jouy en Josas, France., Richard CA; Unité de Virologie et Immunologie Moléculaires, INRAe, Université Paris Saclay, Jouy en Josas, France., Helle F; Agents infectieux résistance et chimiothérapie Research Unit, UR4294, Jules Verne University of Picardie, Amiens, France., Le Poder S; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France., Klonjkowski B; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France., Meunier N; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France., Zientara S; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France., Paul S; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, Université de Lyon, Inserm, Université Claude Bernard, ENS Lyon, France., Mévélec MN; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Aubrey N; BioMAP, UMR ISP1282 INRAe-Université, Tours, France., Epardaud M; BioMAP, UMR ISP1282 INRAe-Université, Tours, France. mathieu.epardaud@inrae.fr., Dimier-Poisson I; BioMAP, UMR ISP1282 INRAe-Université, Tours, France. isabelle.poisson@univ-tours.fr.
Source: NPJ vaccines [NPJ Vaccines] 2025 Apr 18; Vol. 10 (1), pp. 75. Date of Electronic Publication: 2025 Apr 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants.
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  Data: <searchLink fieldCode="AU" term="%22Lakhrif+Z%22">Lakhrif Z</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Poupée-Beaugé+A%22">Poupée-Beaugé A</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Boursin+F%22">Boursin F</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Ducournau+C%22">Ducournau C</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Lantier+L%22">Lantier L</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Moiré+N%22">Moiré N</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Carpentier+R%22">Carpentier R</searchLink>; Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France.<br /><searchLink fieldCode="AU" term="%22Rossignol+C%22">Rossignol C</searchLink>; INRAe, Université de Tours, ISP, Nouzilly, France.<br /><searchLink fieldCode="AU" term="%22Maquart+M%22">Maquart M</searchLink>; MAVIVH, INSERM U1259, Université de Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Jospin+F%22">Jospin F</searchLink>; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, Université de Lyon, Inserm, Université Claude Bernard, ENS Lyon, France.; Immunology Laboratory, Reference Center 21 iBioThera, CHU Saint-Étienne, Saint-Étienne, France.<br /><searchLink fieldCode="AU" term="%22Merat+L%22">Merat L</searchLink>; INRAE, UE-1277 Plateforme d'Infectiologie Expérimentale (PFIE), Centre de Recherche Val de Loire, Nouzilly, France.<br /><searchLink fieldCode="AU" term="%22Caul-Futy+M%22">Caul-Futy M</searchLink>; Epithelix Sarl, 18 Chemin des Aulx, Plan-les-Ouates, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Yazdanpanah+Y%22">Yazdanpanah Y</searchLink>; ANRS|Emerging Infectious Diseases/Inserm, Paris, France. Service de Maladies Infectieuses et Tropicales, Hôpital Bichat, AP-HP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bouakane+A%22">Bouakane A</searchLink>; ANRS|Emerging Infectious Diseases/Inserm, Paris, France.<br /><searchLink fieldCode="AU" term="%22Riou+M%22">Riou M</searchLink>; INRAE, UE-1277 Plateforme d'Infectiologie Expérimentale (PFIE), Centre de Recherche Val de Loire, Nouzilly, France.<br /><searchLink fieldCode="AU" term="%22Touzé+A%22">Touzé A</searchLink>; Biologie des infections à Polyomavirus team, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Eléouët+JF%22">Eléouët JF</searchLink>; Unité de Virologie et Immunologie Moléculaires, INRAe, Université Paris Saclay, Jouy en Josas, France.<br /><searchLink fieldCode="AU" term="%22Richard+CA%22">Richard CA</searchLink>; Unité de Virologie et Immunologie Moléculaires, INRAe, Université Paris Saclay, Jouy en Josas, France.<br /><searchLink fieldCode="AU" term="%22Helle+F%22">Helle F</searchLink>; Agents infectieux résistance et chimiothérapie Research Unit, UR4294, Jules Verne University of Picardie, Amiens, France.<br /><searchLink fieldCode="AU" term="%22Le+Poder+S%22">Le Poder S</searchLink>; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France.<br /><searchLink fieldCode="AU" term="%22Klonjkowski+B%22">Klonjkowski B</searchLink>; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France.<br /><searchLink fieldCode="AU" term="%22Meunier+N%22">Meunier N</searchLink>; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France.<br /><searchLink fieldCode="AU" term="%22Zientara+S%22">Zientara S</searchLink>; UMR VIROLOGIE, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, France.<br /><searchLink fieldCode="AU" term="%22Paul+S%22">Paul S</searchLink>; CIRI, Centre International de Recherche en Infectiologie, GIMAP team, Université de Lyon, Inserm, Université Claude Bernard, ENS Lyon, France.<br /><searchLink fieldCode="AU" term="%22Mévélec+MN%22">Mévélec MN</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Aubrey+N%22">Aubrey N</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France.<br /><searchLink fieldCode="AU" term="%22Epardaud+M%22">Epardaud M</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France. mathieu.epardaud@inrae.fr.<br /><searchLink fieldCode="AU" term="%22Dimier-Poisson+I%22">Dimier-Poisson I</searchLink>; BioMAP, UMR ISP1282 INRAe-Université, Tours, France. isabelle.poisson@univ-tours.fr.
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  Data: <searchLink fieldCode="JN" term="%22101699863%22">NPJ vaccines</searchLink> [NPJ Vaccines] 2025 Apr 18; Vol. 10 (1), pp. 75. <i>Date of Electronic Publication: </i>2025 Apr 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature+in+partnership+with+the+Sealy+Center+for+Vaccine+Development%22">Springer Nature in partnership with the Sealy Center for Vaccine Development </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101699863 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-0105 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220590105%22">20590105 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Vaccines <i>Subsets: </i>PubMed not MEDLINE
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