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Anti-SARS-CoV-2 Small Molecule Targeting of Oxysterol-Binding Protein (OSBP) Activates Cellular Antiviral Innate Immunity.

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Title: Anti-SARS-CoV-2 Small Molecule Targeting of Oxysterol-Binding Protein (OSBP) Activates Cellular Antiviral Innate Immunity.
Authors: Subramaniyan B; Department of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Falcon EC; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States., Moore AR; Department of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Larabee JL; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Nimmo SL; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States., Berrios-Rivera JL; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States., Reddig WJ; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma 74107, United States., Blewett EL; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma 74107, United States., Papin JF; Department of Pathology, Division of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma 73104, United States., Walters MS; Department of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Burgett AWG; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States.
Source: ACS infectious diseases [ACS Infect Dis] 2025 May 09; Vol. 11 (5), pp. 1064-1077. Date of Electronic Publication: 2025 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Subramaniyan+B%22">Subramaniyan B</searchLink>; Department of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States.<br /><searchLink fieldCode="AU" term="%22Falcon+EC%22">Falcon EC</searchLink>; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States.<br /><searchLink fieldCode="AU" term="%22Moore+AR%22">Moore AR</searchLink>; Department of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States.<br /><searchLink fieldCode="AU" term="%22Larabee+JL%22">Larabee JL</searchLink>; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States.<br /><searchLink fieldCode="AU" term="%22Nimmo+SL%22">Nimmo SL</searchLink>; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States.<br /><searchLink fieldCode="AU" term="%22Berrios-Rivera+JL%22">Berrios-Rivera JL</searchLink>; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States.<br /><searchLink fieldCode="AU" term="%22Reddig+WJ%22">Reddig WJ</searchLink>; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma 74107, United States.<br /><searchLink fieldCode="AU" term="%22Blewett+EL%22">Blewett EL</searchLink>; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma 74107, United States.<br /><searchLink fieldCode="AU" term="%22Papin+JF%22">Papin JF</searchLink>; Department of Pathology, Division of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma 73104, United States.<br /><searchLink fieldCode="AU" term="%22Walters+MS%22">Walters MS</searchLink>; Department of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States.<br /><searchLink fieldCode="AU" term="%22Burgett+AWG%22">Burgett AWG</searchLink>; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, United States.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States.
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  Data: <searchLink fieldCode="JN" term="%22101654580%22">ACS infectious diseases</searchLink> [ACS Infect Dis] 2025 May 09; Vol. 11 (5), pp. 1064-1077. <i>Date of Electronic Publication: </i>2025 Apr 21.
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