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Challenges in the selection and measurement of outcomes in psychiatric trials.

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Title: Challenges in the selection and measurement of outcomes in psychiatric trials.
Authors: Juul S; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark sophie.juul@regionh.dk.; Stolpegaard Psychotherapy Centre, Mental health services in the Capital Region of Denmark, Gentofte, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark., Faltermeier P; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Siddiqui F; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Petersen JJ; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Kamp CB; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Jakobsen RH; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Thabane L; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.; Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa., Moncrieff J; Division of Psychiatry, University College London, London, UK.; Research and Development Department, North East London NHS Foundation Trust (NELFT), London, UK., Horowitz M; Research and Development Department, North East London NHS Foundation Trust (NELFT), London, UK.; Institute of Pharmaceutical Sciences, King's College London, London, UK., Samaan Z; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada., Hengartner MP; Department of Applied Psychology, Kalaidos University of Applied Sciences, Zürich, Switzerland., Mbuagbaw L; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada., Olsen MH; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Gluud C; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Jakobsen JC; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Source: BMJ evidence-based medicine [BMJ Evid Based Med] 2026 Mar 20; Vol. 31 (2), pp. 75-78. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101719009 Publication Model: Electronic Cited Medium: Internet ISSN: 2515-4478 (Electronic) Linking ISSN: 2515446X NLM ISO Abbreviation: BMJ Evid Based Med Subsets: MEDLINE; In Process
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  Data: <searchLink fieldCode="AU" term="%22Juul+S%22">Juul S</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark sophie.juul@regionh.dk.; Stolpegaard Psychotherapy Centre, Mental health services in the Capital Region of Denmark, Gentofte, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Faltermeier+P%22">Faltermeier P</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Siddiqui+F%22">Siddiqui F</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Petersen+JJ%22">Petersen JJ</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kamp+CB%22">Kamp CB</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+RH%22">Jakobsen RH</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Thabane+L%22">Thabane L</searchLink>; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.; Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Moncrieff+J%22">Moncrieff J</searchLink>; Division of Psychiatry, University College London, London, UK.; Research and Development Department, North East London NHS Foundation Trust (NELFT), London, UK.<br /><searchLink fieldCode="AU" term="%22Horowitz+M%22">Horowitz M</searchLink>; Research and Development Department, North East London NHS Foundation Trust (NELFT), London, UK.; Institute of Pharmaceutical Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Samaan+Z%22">Samaan Z</searchLink>; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hengartner+MP%22">Hengartner MP</searchLink>; Department of Applied Psychology, Kalaidos University of Applied Sciences, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mbuagbaw+L%22">Mbuagbaw L</searchLink>; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Olsen+MH%22">Olsen MH</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gluud+C%22">Gluud C</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+JC%22">Jakobsen JC</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
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