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Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks.

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Title: Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks.
Authors: Frei MS; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. michelle.frei@org.chem.ethz.ch.; Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland. michelle.frei@org.chem.ethz.ch., Sanchez SA; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., He X; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Liu L; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA., Schneider F; Translational Imaging Center, University of Southern California, Los Angeles, CA, USA.; Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA., Wang Z; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Hakozaki H; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Li Y; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Lyons AC; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Rohm TV; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Olefsky JM; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Shi L; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Schöneberg J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Fraser SE; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.; Translational Imaging Center, University of Southern California, Los Angeles, CA, USA.; Department of Biological Sciences, Division of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA., Mehta S; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Wang Y; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA., Zhang J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.
Source: Nature biotechnology [Nat Biotechnol] 2026 Mar; Vol. 44 (3), pp. 444-453. Date of Electronic Publication: 2025 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks.
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  Data: <searchLink fieldCode="AU" term="%22Frei+MS%22">Frei MS</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. michelle.frei@org.chem.ethz.ch.; Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland. michelle.frei@org.chem.ethz.ch.<br /><searchLink fieldCode="AU" term="%22Sanchez+SA%22">Sanchez SA</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+F%22">Schneider F</searchLink>; Translational Imaging Center, University of Southern California, Los Angeles, CA, USA.; Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hakozaki+H%22">Hakozaki H</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lyons+AC%22">Lyons AC</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rohm+TV%22">Rohm TV</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Olefsky+JM%22">Olefsky JM</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+L%22">Shi L</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schöneberg+J%22">Schöneberg J</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fraser+SE%22">Fraser SE</searchLink>; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.; Translational Imaging Center, University of Southern California, Los Angeles, CA, USA.; Department of Biological Sciences, Division of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+S%22">Mehta S</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. jzhang32@health.ucsd.edu.
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  Data: <searchLink fieldCode="JN" term="%229604648%22">Nature biotechnology</searchLink> [Nat Biotechnol] 2026 Mar; Vol. 44 (3), pp. 444-453. <i>Date of Electronic Publication: </i>2025 Apr 21.
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