Opposing roles for GSK3β and ERK1-dependent phosphorylation of huntingtin during neuronal dysfunction and cell death in Huntington's disease.

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Title: Opposing roles for GSK3β and ERK1-dependent phosphorylation of huntingtin during neuronal dysfunction and cell death in Huntington's disease.
Authors: Krzystek TJ; Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA., Rathnayake R; Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA., Zeng J; Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA., Huang J; Neuroscience Program, The State University of New York at Buffalo, Buffalo, NY, USA., Iacobucci G; Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA., Yu MC; Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA., Gunawardena S; Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA. sg99@buffalo.edu.
Source: Cell death & disease [Cell Death Dis] 2025 Apr 22; Vol. 16 (1), pp. 328. Date of Electronic Publication: 2025 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-025-07524-0