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Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials.

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Title: Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials.
Authors: Glenn AJ; Department of Nutrition and Food Studies, New York University, New York, NY, USA. a.glenn@nyu.edu.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. a.glenn@nyu.edu.; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. a.glenn@nyu.edu.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada. a.glenn@nyu.edu., Tessier AJ; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal, QC, Canada.; Montreal Heart Institute, Montreal, QC, Canada.; Institut de Valorisation des Données (IVADO), Montreal, QC, Canada., Kavanagh ME; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada., Morgan GA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.; School of Nutrition, Toronto Metropolitan University, Toronto, ON, Canada., Clish CB; Metabolomics Platform, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Salas-Salvado J; CIBER Fisiopatologıa de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigacions Sanitàries Pere i Virgili, Universitat Rovira i Virgili, Reus, Spain., Malik VS; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Hanley AJ; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Bazinet RP; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Comelli EM; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., El-Sohemy A; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Liu S; Department of Epidemiology and Biostatistics, Joe C. Wen School of Population & Public Health, UC Irvine, Irvine, CA, USA.; Center for Global Cardiometabolic Health & Nutrition (CGCHN), Mary & Steve Wen Division of Cardiology, Department of Medicine, School of Medicine, UC Irvine, Irvine, CA, USA.; Division of Endocrinology Department of Medicine, and Division of Cardiothoracic Surgery Department of Surgery, Warren Alpert School of Medicine and Rhode Island Hospital, Providence, RI, USA.; Department of Epidemiology, Brown University, School of Public Health, Providence, RI, USA., Boucher BA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Kendall CWC; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada., Jenkins DJA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Hu FB; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Sievenpiper JL; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.
Source: European journal of clinical nutrition [Eur J Clin Nutr] 2025 Sep; Vol. 79 (9), pp. 863-875. Date of Electronic Publication: 2025 Apr 22.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5640 (Electronic) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials.
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  Data: <searchLink fieldCode="AU" term="%22Glenn+AJ%22">Glenn AJ</searchLink>; Department of Nutrition and Food Studies, New York University, New York, NY, USA. a.glenn@nyu.edu.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. a.glenn@nyu.edu.; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. a.glenn@nyu.edu.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada. a.glenn@nyu.edu.<br /><searchLink fieldCode="AU" term="%22Tessier+AJ%22">Tessier AJ</searchLink>; Department of Nutrition, Harvard T.H. 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Chan School of Public Health, Boston, MA, USA.; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hanley+AJ%22">Hanley AJ</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bazinet+RP%22">Bazinet RP</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Comelli+EM%22">Comelli EM</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22El-Sohemy+A%22">El-Sohemy A</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Epidemiology and Biostatistics, Joe C. Wen School of Population & Public Health, UC Irvine, Irvine, CA, USA.; Center for Global Cardiometabolic Health & Nutrition (CGCHN), Mary & Steve Wen Division of Cardiology, Department of Medicine, School of Medicine, UC Irvine, Irvine, CA, USA.; Division of Endocrinology Department of Medicine, and Division of Cardiothoracic Surgery Department of Surgery, Warren Alpert School of Medicine and Rhode Island Hospital, Providence, RI, USA.; Department of Epidemiology, Brown University, School of Public Health, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Boucher+BA%22">Boucher BA</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kendall+CWC%22">Kendall CWC</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.<br /><searchLink fieldCode="AU" term="%22Jenkins+DJA%22">Jenkins DJA</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hu+FB%22">Hu FB</searchLink>; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sievenpiper+JL%22">Sievenpiper JL</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. john.sievenpiper@utoronto.ca.
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