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Geographic and age variations in mutational processes in colorectal cancer.

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Title: Geographic and age variations in mutational processes in colorectal cancer.
Authors: Díaz-Gay M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Digital Genomics Group, Structural Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Dos Santos W; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Moody S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Kazachkova M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA., Abbasi A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Steele CD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Vangara R; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Senkin S; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Wang J; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Fitzgerald S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Bergstrom EN; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Khandekar A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Otlu B; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey., Abedi-Ardekani B; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., de Carvalho AC; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Cattiaux T; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Penha RCC; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Gaborieau V; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Chopard P; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Carreira C; Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Cheema S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Latimer C; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Teague JW; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Mukeriya A; Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Zaridze D; Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Cox R; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Albert M; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Centre for Biodiversity Genomics, University of Guelph, Guelph, Ontario, Canada., Phouthavongsy L; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Gallinger S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Malekzadeh R; Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Niavarani A; Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Miladinov M; Clinic for Digestive Surgery-First Surgical Clinic, University Clinical Centre of Serbia, Belgrade, Serbia., Erić K; Department of Pathology, University Clinical Centre of Serbia, Belgrade, Serbia., Milosavljevic S; International Organization for Cancer Prevention and Research, Belgrade, Serbia., Sangrajrang S; National Cancer Institute, Bangkok, Thailand., Curado MP; Department of Epidemiology, A. C. Camargo Cancer Center, Sao Paulo, Brazil., Aguiar S; Colon Cancer Reference Center, A. C. Camargo Cancer Center, Sao Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Medicine, Minho University, Braga, Portugal., Reis MT; Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil., Romagnolo LG; Department of Colorectal Oncology Surgery, Barretos Cancer Hospital, Barretos, Brazil., Guimarães DP; Department of Endoscopy, Barretos Cancer Hospital, Barretos, Brazil., Holcatova I; Department of Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.; Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic., Kalvach J; Surgery Department, 2nd Faculty of Medicine, Charles University and Central Military Hospital, Prague, Czech Republic.; 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.; Institute of Animal Physiology and Genetics Czech Academy of Science, Libechov, Czech Republic.; Clinical Center ISCARE, Prague, Czech Republic., Vaccaro CA; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)-CONICET-Universidad Hospital Italiano de Buenos Aires (UHIBA) y Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina., Piñero TA; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)-CONICET-Universidad Hospital Italiano de Buenos Aires (UHIBA) y Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina., Świątkowska B; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland., Lissowska J; The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland., Roszkowska-Purska K; Department of Pathology, The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland., Huertas-Salgado A; Oncological Pathology Group, Terry Fox National Tumor Bank (Banco Nacional de Tumores Terry Fox), National Cancer Institute, Bogotá, Colombia., Shibata T; Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan., Shiba S; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan., Sangkhathat S; Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.; Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand., Chitapanarux T; Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Roshandel G; Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran., Ashton-Prolla P; Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil., Damin DC; Department of Surgery, Division of Colorectal Surgery, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil., de Oliveira FH; Department of Pathology, Anatomic Pathology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil., Humphreys L; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Lawley TD; Parasites and Microbes, Wellcome Sanger Institute, Cambridge, UK., Perdomo S; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Stratton MR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Brennan P; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Alexandrov LB; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.
Source: Nature [Nature] 2025 Jul; Vol. 643 (8070), pp. 230-240. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Geographic and age variations in mutational processes in colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Díaz-Gay+M%22">Díaz-Gay M</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Digital Genomics Group, Structural Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+W%22">Dos Santos W</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Moody+S%22">Moody S</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kazachkova+M%22">Kazachkova M</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Abbasi+A%22">Abbasi A</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Steele+CD%22">Steele CD</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vangara+R%22">Vangara R</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; 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Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Brennan+P%22">Brennan P</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Alexandrov+LB%22">Alexandrov LB</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.
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          Dates:
            – D: 01
              M: 07
              Text: 2025 Jul
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
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              Value: 643
            – Type: issue
              Value: 8070
          Titles:
            – TitleFull: Nature
              Type: main
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