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Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression.

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Title: Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression.
Authors: Vinayak V; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA., Basir R; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA., Golloshi R; Departments of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Giovanis Institute for Translational Cell Biology, Johns Hopkins Medicine, Baltimore, MD, USA., Toth J; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA., Sant'Anna L; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA., Lakadamyali M; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., McCord RP; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA., Shenoy VB; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA. vshenoy@seas.upenn.edu.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA. vshenoy@seas.upenn.edu.
Source: Nature communications [Nat Commun] 2025 Apr 23; Vol. 16 (1), pp. 3816. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Vinayak+V%22">Vinayak V</searchLink>; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Basir+R%22">Basir R</searchLink>; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Golloshi+R%22">Golloshi R</searchLink>; Departments of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Giovanis Institute for Translational Cell Biology, Johns Hopkins Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Toth+J%22">Toth J</searchLink>; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sant'Anna+L%22">Sant'Anna L</searchLink>; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lakadamyali+M%22">Lakadamyali M</searchLink>; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22McCord+RP%22">McCord RP</searchLink>; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shenoy+VB%22">Shenoy VB</searchLink>; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA. vshenoy@seas.upenn.edu.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA. vshenoy@seas.upenn.edu.
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