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Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity.

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Title: Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity.
Authors: Hou D; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Wang S; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Castro BA; Department of Neurosurgery, University of Chicago, Chicago, Illinois, USA., Katz JL; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Dapash M; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Arrieta VA; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Vazquez-Cervantes GI; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Wan H; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Billingham LK; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Du R; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Murphy AR; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Lopez-Rosas A; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Han Y; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Patel RV; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Chia TY; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Dmello CC; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Zhang P; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Sheppard D; Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA., Sonabend AM; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Miska JM; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Lesniak MS; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA., Heiland DH; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.; Translational Neurosurgery, Alexander-Friedrich-Universität Erlangen-Nürnberg, Erlangen, Germany.; Neurosurgical Clinic, University Clinic, Alexander-Friedrich-Universität Erlangen-Nürnberg, Erlangen, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center-University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK) partner site, Freiburg, Germany., Lee-Chang C; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.
Source: Neuro-oncology [Neuro Oncol] 2025 Oct 14; Vol. 27 (9), pp. 2355-2369.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hou+D%22">Hou D</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Castro+BA%22">Castro BA</searchLink>; Department of Neurosurgery, University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Katz+JL%22">Katz JL</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Dapash+M%22">Dapash M</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Arrieta+VA%22">Arrieta VA</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Vazquez-Cervantes+GI%22">Vazquez-Cervantes GI</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Wan+H%22">Wan H</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Billingham+LK%22">Billingham LK</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Du+R%22">Du R</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+AR%22">Murphy AR</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Lopez-Rosas+A%22">Lopez-Rosas A</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Patel+RV%22">Patel RV</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Chia+TY%22">Chia TY</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Dmello+CC%22">Dmello CC</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Sheppard+D%22">Sheppard D</searchLink>; Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Sonabend+AM%22">Sonabend AM</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Miska+JM%22">Miska JM</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Lesniak+MS%22">Lesniak MS</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Heiland+DH%22">Heiland DH</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.; Translational Neurosurgery, Alexander-Friedrich-Universität Erlangen-Nürnberg, Erlangen, Germany.; Neurosurgical Clinic, University Clinic, Alexander-Friedrich-Universität Erlangen-Nürnberg, Erlangen, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center-University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK) partner site, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lee-Chang+C%22">Lee-Chang C</searchLink>; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Lou and Jean Malnati Brain Tumor Institute, Chicago, Illinois, USA.
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