Engineering neuronal networks in granular microgels to innervate bioprinted cancer organoids on-a-chip.

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Title: Engineering neuronal networks in granular microgels to innervate bioprinted cancer organoids on-a-chip.
Authors: Fredrikson JP; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA., Roth DM; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA., Cosgrove JA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA., Sener G; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA., Crow LA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA., Eckenstein K; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA., Wu L; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA., Hosseini M; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97201, USA., Thomas G; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, 97201, USA., Eksi SE; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA., Bertassoni L; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97201, USA.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.
Source: Lab on a chip [Lab Chip] 2025 Jul 08; Vol. 25 (14), pp. 3467-3481. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Fredrikson+JP%22">Fredrikson JP</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Roth+DM%22">Roth DM</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Cosgrove+JA%22">Cosgrove JA</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Sener+G%22">Sener G</searchLink>; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Crow+LA%22">Crow LA</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Eckenstein+K%22">Eckenstein K</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Hosseini+M%22">Hosseini M</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+G%22">Thomas G</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, 97201, USA.<br /><searchLink fieldCode="AU" term="%22Eksi+SE%22">Eksi SE</searchLink>; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.<br /><searchLink fieldCode="AU" term="%22Bertassoni+L%22">Bertassoni L</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA. bertasso@ohsu.edu.; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97201, USA.; Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97201, USA.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.
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        Value: 10.1039/d5lc00134j
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