A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.
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| Title: | A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model. |
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| Authors: | Pons-Grífols A; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Tarrés-Freixas F; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Pérez M; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain., Riveira-Muñoz E; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Raïch-Regué D; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Perez-Zsolt D; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Muñoz-Basagoiti J; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Tondelli B; Mouse Mutant Core Facility, Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Barcelona, Spain., Pradenas E; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Izquierdo-Useros N; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain., Capdevila S; Comparative Medicine and Bioimage Centre of Catalonia (CMCiB), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Vergara-Alert J; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain., Urrea V; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Carrillo J; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain., Ballana E; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Forrow S; Mouse Mutant Core Facility, Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Barcelona, Spain., Clotet B; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Segalés J; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona (UAB), Campus de la UAB, Bellaterra, Spain., Trinité B; IrsiCaixa, Can Ruti Campus, Badalona, Spain., Blanco J; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain. |
| Source: | MBio [mBio] 2025 May 14; Vol. 16 (5), pp. e0072025. Date of Electronic Publication: 2025 Apr 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40272151 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Pons-Grífols+A%22">Pons-Grífols A</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Tarrés-Freixas+F%22">Tarrés-Freixas F</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez+M%22">Pérez M</searchLink>; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Riveira-Muñoz+E%22">Riveira-Muñoz E</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Raïch-Regué+D%22">Raïch-Regué D</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Perez-Zsolt+D%22">Perez-Zsolt D</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz-Basagoiti+J%22">Muñoz-Basagoiti J</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Tondelli+B%22">Tondelli B</searchLink>; Mouse Mutant Core Facility, Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pradenas+E%22">Pradenas E</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Izquierdo-Useros+N%22">Izquierdo-Useros N</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Capdevila+S%22">Capdevila S</searchLink>; Comparative Medicine and Bioimage Centre of Catalonia (CMCiB), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Vergara-Alert+J%22">Vergara-Alert J</searchLink>; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Urrea+V%22">Urrea V</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Carrillo+J%22">Carrillo J</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ballana+E%22">Ballana E</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Forrow+S%22">Forrow S</searchLink>; Mouse Mutant Core Facility, Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Clotet+B%22">Clotet B</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.<br /><searchLink fieldCode="AU" term="%22Segalés+J%22">Segalés J</searchLink>; Unitat mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona (UAB), Campus de la UAB, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Trinité+B%22">Trinité B</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Blanco+J%22">Blanco J</searchLink>; IrsiCaixa, Can Ruti Campus, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBER Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2025 May 14; Vol. 16 (5), pp. e0072025. <i>Date of Electronic Publication: </i>2025 Apr 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101519231 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2150-7511 (Electronic) <i>NLM ISO Abbreviation: </i>mBio <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40272151 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1128/mbio.00720-25 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0072025 Titles: – TitleFull: A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pons-Grífols A – PersonEntity: Name: NameFull: Tarrés-Freixas F – PersonEntity: Name: NameFull: Pérez M – PersonEntity: Name: NameFull: Riveira-Muñoz E – PersonEntity: Name: NameFull: Raïch-Regué D – PersonEntity: Name: NameFull: Perez-Zsolt D – PersonEntity: Name: NameFull: Muñoz-Basagoiti J – PersonEntity: Name: NameFull: Tondelli B – PersonEntity: Name: NameFull: Pradenas E – PersonEntity: Name: NameFull: Izquierdo-Useros N – PersonEntity: Name: NameFull: Capdevila S – PersonEntity: Name: NameFull: Vergara-Alert J – PersonEntity: Name: NameFull: Urrea V – PersonEntity: Name: NameFull: Carrillo J – PersonEntity: Name: NameFull: Ballana E – PersonEntity: Name: NameFull: Forrow S – PersonEntity: Name: NameFull: Clotet B – PersonEntity: Name: NameFull: Segalés J – PersonEntity: Name: NameFull: Trinité B – PersonEntity: Name: NameFull: Blanco J IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 05 Text: 2025 May 14 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2150-7511 Numbering: – Type: volume Value: 16 – Type: issue Value: 5 Titles: – TitleFull: MBio Type: main |
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