Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data.

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Title: Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data.
Authors: Costanzo MC; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA., Akolkar B; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Claussnitzer M; Broad Diabetes Initiative and Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Endocrine Division, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA., Florez JC; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA.; Department of Medicine, Mass General Brigham, Boston, MA., Gloyn AL; Department of Pediatrics, Department of Genetics, and Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Palo Alto, CA., Grant SFA; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Divisions of Human Genetics and Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA., Kaestner KH; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Manning AK; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA.; Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Parker SCJ; Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI.; Department of Human Genetics, University of Michigan, Ann Arbor, MI.; Department of Biostatistics, University of Michigan, Ann Arbor, MI., Titchenell PM; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Udler MS; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA.; Department of Medicine, Mass General Brigham, Boston, MA., Jones MA; Foundation for the National Institutes of Health, North Bethesda, MD., Kamphaus TN; Foundation for the National Institutes of Health, North Bethesda, MD., Fischer RA; Foundation for the National Institutes of Health, North Bethesda, MD., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K., Miller MR; Internal Medicine Research Unit, Pfizer Research and Development, Pfizer, Cambridge, MA., Boehnke M; Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI., Flannick J; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA.; Department of Pediatrics, Harvard Medical School, Boston, MA., Burtt NP; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.
Corporate Authors: AMP T2D Consortium, AMP CMD Consortium
Source: Diabetes [Diabetes] 2025 Jul 01; Vol. 74 (7), pp. 1089-1098.
Publication Type: Journal Article; Review
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Costanzo+MC%22">Costanzo MC</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Akolkar+B%22">Akolkar B</searchLink>; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Claussnitzer+M%22">Claussnitzer M</searchLink>; Broad Diabetes Initiative and Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Endocrine Division, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Florez+JC%22">Florez JC</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA.; Department of Medicine, Mass General Brigham, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Gloyn+AL%22">Gloyn AL</searchLink>; Department of Pediatrics, Department of Genetics, and Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Grant+SFA%22">Grant SFA</searchLink>; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Divisions of Human Genetics and Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Kaestner+KH%22">Kaestner KH</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Manning+AK%22">Manning AK</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA.; Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Mohlke+KL%22">Mohlke KL</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Parker+SCJ%22">Parker SCJ</searchLink>; Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI.; Department of Human Genetics, University of Michigan, Ann Arbor, MI.; Department of Biostatistics, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Titchenell+PM%22">Titchenell PM</searchLink>; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Udler+MS%22">Udler MS</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Harvard University, Boston, MA.; Department of Medicine, Mass General Brigham, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Jones+MA%22">Jones MA</searchLink>; Foundation for the National Institutes of Health, North Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Kamphaus+TN%22">Kamphaus TN</searchLink>; Foundation for the National Institutes of Health, North Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Fischer+RA%22">Fischer RA</searchLink>; Foundation for the National Institutes of Health, North Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22McCarthy+MI%22">McCarthy MI</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K.<br /><searchLink fieldCode="AU" term="%22Miller+MR%22">Miller MR</searchLink>; Internal Medicine Research Unit, Pfizer Research and Development, Pfizer, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Flannick+J%22">Flannick J</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA.; Department of Pediatrics, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Burtt+NP%22">Burtt NP</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.
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  Data: <searchLink fieldCode="JN" term="%220372763%22">Diabetes</searchLink> [Diabetes] 2025 Jul 01; Vol. 74 (7), pp. 1089-1098.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372763 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1939-327X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200121797%22">00121797 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes <i>Subsets: </i>MEDLINE
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        Value: 10.2337/db25-0042
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