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PANTAX: a phase Ib clinical trial of the efflux pump inhibitor SCO-101 in combination with gemcitabine and nab-paclitaxel in non-resectable or metastatic pancreatic cancer.

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Title: PANTAX: a phase Ib clinical trial of the efflux pump inhibitor SCO-101 in combination with gemcitabine and nab-paclitaxel in non-resectable or metastatic pancreatic cancer.
Authors: Shim S; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18 - 22, 9000, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Reinacher-Schick A; Dept. of Hematology, Oncology and Palliative Care, St. Josef-Hospital, Bochum, Germany., Kraeft AL; Dept. of Hematology, Oncology and Palliative Care, St. Josef-Hospital, Bochum, Germany., Per Pfeiffer; Department of Oncology, Odense University Hospital, Odense, Denmark.; University of Southern Denmark, Odense, Denmark., Tarpgaard LS; Department of Oncology, Odense University Hospital, Odense, Denmark.; University of Southern Denmark, Odense, Denmark., Ettrich TJ; Department of Internal Medicine I, University Hospital of Ulm - Oberer Eselsberg, Ulm, Germany., Kestler A; Department of Internal Medicine I, University Hospital of Ulm - Oberer Eselsberg, Ulm, Germany., Christensen S; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18 - 22, 9000, Aalborg, Denmark., Jandu H; Scandion Oncology A/S, Copenhagen, Denmark., Nawabi M; Scandion Oncology A/S, Copenhagen, Denmark., Roest NL; Scandion Oncology A/S, Copenhagen, Denmark., Damstrup L; Scandion Oncology A/S, Copenhagen, Denmark., Vestlev PM; Scandion Oncology A/S, Copenhagen, Denmark., Brünner N; Scandion Oncology A/S, Copenhagen, Denmark., Stenvang J; Scandion Oncology A/S, Copenhagen, Denmark., Ladekarl M; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18 - 22, 9000, Aalborg, Denmark. morten.ladekarl@rn.dk.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. morten.ladekarl@rn.dk.
Source: Investigational new drugs [Invest New Drugs] 2025 Apr; Vol. 43 (2), pp. 337-347. Date of Electronic Publication: 2025 Apr 24.
Publication Type: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PANTAX: a phase Ib clinical trial of the efflux pump inhibitor SCO-101 in combination with gemcitabine and nab-paclitaxel in non-resectable or metastatic pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Shim+S%22">Shim S</searchLink>; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18 - 22, 9000, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Reinacher-Schick+A%22">Reinacher-Schick A</searchLink>; Dept. of Hematology, Oncology and Palliative Care, St. Josef-Hospital, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Kraeft+AL%22">Kraeft AL</searchLink>; Dept. of Hematology, Oncology and Palliative Care, St. Josef-Hospital, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Per+Pfeiffer%22">Per Pfeiffer</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.; University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Tarpgaard+LS%22">Tarpgaard LS</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.; University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Ettrich+TJ%22">Ettrich TJ</searchLink>; Department of Internal Medicine I, University Hospital of Ulm - Oberer Eselsberg, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Kestler+A%22">Kestler A</searchLink>; Department of Internal Medicine I, University Hospital of Ulm - Oberer Eselsberg, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Christensen+S%22">Christensen S</searchLink>; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18 - 22, 9000, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Jandu+H%22">Jandu H</searchLink>; Scandion Oncology A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nawabi+M%22">Nawabi M</searchLink>; Scandion Oncology A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Roest+NL%22">Roest NL</searchLink>; Scandion Oncology A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Damstrup+L%22">Damstrup L</searchLink>; Scandion Oncology A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Vestlev+PM%22">Vestlev PM</searchLink>; Scandion Oncology A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Brünner+N%22">Brünner N</searchLink>; Scandion Oncology A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Stenvang+J%22">Stenvang J</searchLink>; Scandion Oncology A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ladekarl+M%22">Ladekarl M</searchLink>; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18 - 22, 9000, Aalborg, Denmark. morten.ladekarl@rn.dk.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. morten.ladekarl@rn.dk.
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