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A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization.

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Title: A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization.
Authors: Wang HY; University of Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, PR China., Huang SL; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China., Ren J; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Peng LY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China., Chen LR; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Qi LY; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Zhu KH; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Feng CL; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China., Zhou R; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China., Gu YP; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China., Cao L; University of Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China., Leng Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China., Zhao QS; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China., Tang W; University of Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address: tangwei@simm.ac.cn.
Source: Journal of advanced research [J Adv Res] 2026 Feb; Vol. 80, pp. 627-642. Date of Electronic Publication: 2025 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization.
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  Data: <searchLink fieldCode="AU" term="%22Wang+HY%22">Wang HY</searchLink>; University of Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, PR China.<br /><searchLink fieldCode="AU" term="%22Huang+SL%22">Huang SL</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Ren+J%22">Ren J</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.<br /><searchLink fieldCode="AU" term="%22Peng+LY%22">Peng LY</searchLink>; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+LR%22">Chen LR</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.<br /><searchLink fieldCode="AU" term="%22Qi+LY%22">Qi LY</searchLink>; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.<br /><searchLink fieldCode="AU" term="%22Zhu+KH%22">Zhu KH</searchLink>; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.<br /><searchLink fieldCode="AU" term="%22Feng+CL%22">Feng CL</searchLink>; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Zhou+R%22">Zhou R</searchLink>; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Gu+YP%22">Gu YP</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Cao+L%22">Cao L</searchLink>; University of Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Leng+Y%22">Leng Y</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Zhao+QS%22">Zhao QS</searchLink>; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; University of Chinese Academy of Sciences, Beijing 100049, PR China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address: tangwei@simm.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22101546952%22">Journal of advanced research</searchLink> [J Adv Res] 2026 Feb; Vol. 80, pp. 627-642. <i>Date of Electronic Publication: </i>2025 Apr 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cairo+University%2C+production+and+hosting+by+Elsevier+B%2E+V%22">Cairo University, production and hosting by Elsevier B. V </searchLink><i>Country of Publication: </i>Egypt <i>NLM ID: </i>101546952 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2090-1224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220901224%22">20901224 </searchLink><i>NLM ISO Abbreviation: </i>J Adv Res <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jare.2025.04.034
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        Text: English
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      – TitleFull: A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization.
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              Text: 2026 Feb
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