Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies.
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| Title: | Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies. |
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| Authors: | Galvez-Cancino F; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Immune Regulation Laboratory, Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: felipe.galvez-cancino@immonc.ox.ac.uk., Navarrete M; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Beattie G; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK; Bioinformatics Hub, UCL Cancer Institute, University College London, London, UK., Puccio S; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Institute of Genetic and Biomedical Research, UoS Milan, National Research Council, via Manzoni 56, Rozzano, Milan 20089, Italy., Conde-Gallastegi E; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Foster K; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Morris Y; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Sahwangarrom T; Pre-Cancer Immunology Laboratory, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK., Karagianni D; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Liu J; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Lee AJX; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Garyfallos DA; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Simpson AP; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Mastrokalos GT; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Nannini F; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Costoya C; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Anantharam V; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Cianciotti BC; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Bradley L; Centre for Regenerative Medicine and Institute for Regeneration and Repair, & Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH16 4UU, UK., Garcia-Diaz C; Neurogenesis and Brain Cancer Group, Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK., Clements M; Neurogenesis and Brain Cancer Group, Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK., Shroff A; Centre for Cell Death, Cancer and Inflammation (CCCI), UCL Cancer Institute, London WC1E 6DD, UK., Vahid Dastjerdi F; Recombinant Antibody Therapeutics Group, UCL Cancer Institute, London WC1E 6DD, UK., Rota EM; Recombinant Antibody Therapeutics Group, UCL Cancer Institute, London WC1E 6DD, UK., Sheraz S; Pre-Cancer Immunology Laboratory, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK., Bentham R; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Uddin I; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK., Walczak H; Centre for Cell Death, Cancer and Inflammation (CCCI), UCL Cancer Institute, London WC1E 6DD, UK; Institute of Biochemistry I & CECAD Cluster of Excellence, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Lladser A; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile; Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile., Reading JL; Pre-Cancer Immunology Laboratory, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Chester KA; Recombinant Antibody Therapeutics Group, UCL Cancer Institute, London WC1E 6DD, UK., Pule MA; Research Department of Haematology, Cancer Institute, University College London, Paul O'Gorman Building, London WC1E 6DD, UK., Brennan PM; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK., Marguerat S; Bioinformatics Hub, UCL Cancer Institute, University College London, London, UK., Parrinello S; Neurogenesis and Brain Cancer Group, Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK., Peggs KS; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., McGranahan N; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Lugli E; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Litchfield K; The Tumour Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK., Pollard SM; Centre for Regenerative Medicine and Institute for Regeneration and Repair, & Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH16 4UU, UK., Quezada SA; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK. Electronic address: s.quezada@ucl.ac.uk. |
| Source: | Immunity [Immunity] 2025 May 13; Vol. 58 (5), pp. 1236-1253.e8. Date of Electronic Publication: 2025 Apr 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40280128 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Galvez-Cancino+F%22">Galvez-Cancino F</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Immune Regulation Laboratory, Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: felipe.galvez-cancino@immonc.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Navarrete+M%22">Navarrete M</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Beattie+G%22">Beattie G</searchLink>; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK; Bioinformatics Hub, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Puccio+S%22">Puccio S</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Institute of Genetic and Biomedical Research, UoS Milan, National Research Council, via Manzoni 56, Rozzano, Milan 20089, Italy.<br /><searchLink fieldCode="AU" term="%22Conde-Gallastegi+E%22">Conde-Gallastegi E</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Foster+K%22">Foster K</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Morris+Y%22">Morris Y</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Sahwangarrom+T%22">Sahwangarrom T</searchLink>; Pre-Cancer Immunology Laboratory, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Karagianni+D%22">Karagianni D</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Lee+AJX%22">Lee AJX</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Garyfallos+DA%22">Garyfallos DA</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Simpson+AP%22">Simpson AP</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Mastrokalos+GT%22">Mastrokalos GT</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Nannini+F%22">Nannini F</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Costoya+C%22">Costoya C</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Anantharam+V%22">Anantharam V</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Cianciotti+BC%22">Cianciotti BC</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bradley+L%22">Bradley L</searchLink>; Centre for Regenerative Medicine and Institute for Regeneration and Repair, & Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Garcia-Diaz+C%22">Garcia-Diaz C</searchLink>; Neurogenesis and Brain Cancer Group, Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Clements+M%22">Clements M</searchLink>; Neurogenesis and Brain Cancer Group, Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Shroff+A%22">Shroff A</searchLink>; Centre for Cell Death, Cancer and Inflammation (CCCI), UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Vahid+Dastjerdi+F%22">Vahid Dastjerdi F</searchLink>; Recombinant Antibody Therapeutics Group, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Rota+EM%22">Rota EM</searchLink>; Recombinant Antibody Therapeutics Group, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Sheraz+S%22">Sheraz S</searchLink>; Pre-Cancer Immunology Laboratory, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Bentham+R%22">Bentham R</searchLink>; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Uddin+I%22">Uddin I</searchLink>; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Walczak+H%22">Walczak H</searchLink>; Centre for Cell Death, Cancer and Inflammation (CCCI), UCL Cancer Institute, London WC1E 6DD, UK; Institute of Biochemistry I & CECAD Cluster of Excellence, Medical Faculty, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Lladser+A%22">Lladser A</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile; Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Reading+JL%22">Reading JL</searchLink>; Pre-Cancer Immunology Laboratory, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Chester+KA%22">Chester KA</searchLink>; Recombinant Antibody Therapeutics Group, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Pule+MA%22">Pule MA</searchLink>; Research Department of Haematology, Cancer Institute, University College London, Paul O'Gorman Building, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Brennan+PM%22">Brennan PM</searchLink>; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.<br /><searchLink fieldCode="AU" term="%22Marguerat+S%22">Marguerat S</searchLink>; Bioinformatics Hub, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Parrinello+S%22">Parrinello S</searchLink>; Neurogenesis and Brain Cancer Group, Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Peggs+KS%22">Peggs KS</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22McGranahan+N%22">McGranahan N</searchLink>; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Lugli+E%22">Lugli E</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Litchfield+K%22">Litchfield K</searchLink>; The Tumour Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Pollard+SM%22">Pollard SM</searchLink>; Centre for Regenerative Medicine and Institute for Regeneration and Repair, & Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Quezada+SA%22">Quezada SA</searchLink>; Immune Regulation and Tumour Immunotherapy Laboratory, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK. Electronic address: s.quezada@ucl.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229432918%22">Immunity</searchLink> [Immunity] 2025 May 13; Vol. 58 (5), pp. 1236-1253.e8. <i>Date of Electronic Publication: </i>2025 Apr 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9432918 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4180 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210747613%22">10747613 </searchLink><i>NLM ISO Abbreviation: </i>Immunity <i>Subsets: </i>MEDLINE |
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