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Aetiologies, neuroradiological features, and risk factors for mortality and long-term neurosequelae of febrile coma in Malawian children: a prospective cohort study.

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Title: Aetiologies, neuroradiological features, and risk factors for mortality and long-term neurosequelae of febrile coma in Malawian children: a prospective cohort study.
Authors: Ray STJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; Department of Paediatric Infectious Disease and Immunology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Wilson Lab, Weil Institute for Neurosciences, University of San Francisco, San Francisco, CA, USA. Electronic address: stephen.ray@paediatrics.ox.ac.uk., Fuller CE; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; Department of Paediatric Immunology, Allergy and Infectious Diseases, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK., Ahmadu A; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Kafoteka E; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Muiruri-Liomba A; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Malenga A; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Tebulo A; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Pensulo P; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Gushu MB; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Chilingulo C; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Dwivedi R; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department for Clinical Neurosciences, Western General Hospital, Edinburgh, UK., Chetcuti K; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Attipa C; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Byrne R; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK., Nielsen M; Institute of Infection, Veterinary, and Ecological Sciences, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Rigby J; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK., Stockdale E; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Boubour A; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Henrion MYR; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK., Langton J; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi., Anscombe C; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Flatley J; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK., Prince T; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK., Avula S; Department of Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Birbeck GL; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Neurology, University of Rochester, Rochester, NY, USA., Postels DG; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Division of Neurology, George Washington University and Children's National Health System, Washington, DC, USA., O'Brien N; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital and Ohio State University, Columbus, OH, USA., Cornick J; Institute of Infection, Veterinary, and Ecological Sciences, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Michael BD; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Walton Centre NHS Foundation Trust, Liverpool, UK; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK., Solomon T; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Walton Centre NHS Foundation Trust, Liverpool, UK; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK; The Pandemic Institute, University of Liverpool, Liverpool, UK., Gladstone M; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK., Gordon SB; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK., Chimalizeni Y; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Taylor T; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA., Moxon CA; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Lalloo DG; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK., Seydel K; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA., Griffiths MJ; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Centre for Child and Adolescent Health Research, Western Sydney (Baludarri) Precinct, Faculty of Medicine & Health, University of Sydney, Sydney, NSW, Australia.
Source: The Lancet. Global health [Lancet Glob Health] 2025 Jun; Vol. 13 (6), pp. e1057-e1071. Date of Electronic Publication: 2025 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Aetiologies, neuroradiological features, and risk factors for mortality and long-term neurosequelae of febrile coma in Malawian children: a prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Ray+STJ%22">Ray STJ</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; Department of Paediatric Infectious Disease and Immunology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Wilson Lab, Weil Institute for Neurosciences, University of San Francisco, San Francisco, CA, USA. Electronic address: stephen.ray@paediatrics.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Fuller+CE%22">Fuller CE</searchLink>; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; Department of Paediatric Immunology, Allergy and Infectious Diseases, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Ahmadu+A%22">Ahmadu A</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Kafoteka+E%22">Kafoteka E</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Muiruri-Liomba+A%22">Muiruri-Liomba A</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Malenga+A%22">Malenga A</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Tebulo+A%22">Tebulo A</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Pensulo+P%22">Pensulo P</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Gushu+MB%22">Gushu MB</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Chilingulo+C%22">Chilingulo C</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Dwivedi+R%22">Dwivedi R</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department for Clinical Neurosciences, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Chetcuti+K%22">Chetcuti K</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Attipa+C%22">Attipa C</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Byrne+R%22">Byrne R</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Nielsen+M%22">Nielsen M</searchLink>; Institute of Infection, Veterinary, and Ecological Sciences, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Rigby+J%22">Rigby J</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Stockdale+E%22">Stockdale E</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Boubour+A%22">Boubour A</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Henrion+MYR%22">Henrion MYR</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Langton+J%22">Langton J</searchLink>; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Anscombe+C%22">Anscombe C</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Flatley+J%22">Flatley J</searchLink>; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Prince+T%22">Prince T</searchLink>; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Avula+S%22">Avula S</searchLink>; Department of Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Birbeck+GL%22">Birbeck GL</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Neurology, University of Rochester, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Postels+DG%22">Postels DG</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Division of Neurology, George Washington University and Children's National Health System, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+N%22">O'Brien N</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital and Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cornick+J%22">Cornick J</searchLink>; Institute of Infection, Veterinary, and Ecological Sciences, University of Liverpool, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Michael+BD%22">Michael BD</searchLink>; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Walton Centre NHS Foundation Trust, Liverpool, UK; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Solomon+T%22">Solomon T</searchLink>; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Walton Centre NHS Foundation Trust, Liverpool, UK; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK; The Pandemic Institute, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Gladstone+M%22">Gladstone M</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Gordon+SB%22">Gordon SB</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Chimalizeni+Y%22">Chimalizeni Y</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+T%22">Taylor T</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22Moxon+CA%22">Moxon CA</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Lalloo+DG%22">Lalloo DG</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Seydel+K%22">Seydel K</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Paediatrics and Child Health, Kamzu University of Health Sciences, Blantyre, Malawi; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22Griffiths+MJ%22">Griffiths MJ</searchLink>; The Brain Infection and Inflammation Group, University of Liverpool, Liverpool, UK; Centre for Child and Adolescent Health Research, Western Sydney (Baludarri) Precinct, Faculty of Medicine & Health, University of Sydney, Sydney, NSW, Australia.
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      – PersonEntity:
          Name:
            NameFull: Moxon CA
      – PersonEntity:
          Name:
            NameFull: Lalloo DG
      – PersonEntity:
          Name:
            NameFull: Seydel K
      – PersonEntity:
          Name:
            NameFull: Griffiths MJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2025 Jun
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2214-109X
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: The Lancet. Global health
              Type: main
ResultId 1