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Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria.

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Title: Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria.
Authors: Fiorani M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy. Electronic address: mara.fiorani@uniurb.it., Buffi G; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Bagherlou N; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Canonico B; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., De Matteis R; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Guidarelli A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Montanari M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Battistelli M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Papa S; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Coppo L; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Cerioni L; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Spina A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Cantoni O; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Source: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2025 Aug; Vol. 1872 (6), pp. 119967. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE
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  Data: Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria.
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  Data: <searchLink fieldCode="AU" term="%22Fiorani+M%22">Fiorani M</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy. Electronic address: mara.fiorani@uniurb.it.<br /><searchLink fieldCode="AU" term="%22Buffi+G%22">Buffi G</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Bagherlou+N%22">Bagherlou N</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Canonico+B%22">Canonico B</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22De+Matteis+R%22">De Matteis R</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Guidarelli+A%22">Guidarelli A</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Montanari+M%22">Montanari M</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Battistelli+M%22">Battistelli M</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Papa+S%22">Papa S</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Coppo+L%22">Coppo L</searchLink>; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Cerioni+L%22">Cerioni L</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Spina+A%22">Spina A</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Cantoni+O%22">Cantoni O</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101731731%22">Biochimica et biophysica acta. Molecular cell research</searchLink> [Biochim Biophys Acta Mol Cell Res] 2025 Aug; Vol. 1872 (6), pp. 119967. <i>Date of Electronic Publication: </i>2025 Apr 23.
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