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Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors.

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Title: Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors.
Authors: Srivastava J; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Yadav VK; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Jimenez RV; Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Phadatare PR; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Inamdar NA; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Young MM; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Bacchiocchi A; Yale Dermatology, Yale School of Medicine, Yale University, New Haven, Connecticut., Halaban R; Yale Dermatology, Yale School of Medicine, Yale University, New Haven, Connecticut., Fang B; Department of Molecular Oncology, and, Proteomics & Metabolomics, Moffitt Cancer Center and Research Institute, Tampa, Florida., Pulido AM; Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Tsai KY; Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Smalley KSM; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida., Koomen JM; Yale Dermatology, Yale School of Medicine, Yale University, New Haven, Connecticut., Rodriguez PC; Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, Florida., Premi S; Department of Tumor Microenvironment and Metastasis, Moffitt Cancer Center and Research Institute, Tampa, Florida.
Source: Cancer research [Cancer Res] 2025 Jun 16; Vol. 85 (12), pp. 2268-2287.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors.
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              Text: 2025 Jun 16
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