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Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study).

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Title: Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study).
Authors: Kretschmer JR; Department of Neurology, Hannover Medical School, Hannover, Germany., Tkachenko D; Department of Neurology, Hannover Medical School, Hannover, Germany., Kümpfel T; Institute of Clinical Neuroimmunology, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Havla J; Institute of Clinical Neuroimmunology, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Engels D; Institute of Clinical Neuroimmunology, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Paul F; Department of Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, Experimental and Clinical Research Center and Max Delbrueck Center for Molecular Medicine, Berlin, Germany., Schindler P; Department of Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, Experimental and Clinical Research Center and Max Delbrueck Center for Molecular Medicine, Berlin, Germany., Bellmann-Strobl J; Department of Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, Experimental and Clinical Research Center and Max Delbrueck Center for Molecular Medicine, Berlin, Germany., Berthele A; Department of Neurology, Technical University Munich, Munich, Germany., Giglhuber K; Department of Neurology, Technical University Munich, Munich, Germany., Zappe C; Department of Neurology, Technical University Munich, Munich, Germany., Klotz L; Department of Neurology, University of Münster, Münster, Germany., Revie L; Department of Neurology, University of Münster, Münster, Germany., Dawin E; Department of Neurology, University of Münster, Münster, Germany., Senel M; Department of Neurology, University of Ulm, Ulm, Germany., Tumani H; Department of Neurology, University of Ulm, Ulm, Germany., Bergh FT; Department of Neurology, University of Leipzig, Leipzig, Germany., Warnke C; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Kraemer M; Department of Neurology, Alfried Krupp Hospital Essen, Essen, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Walter A; Department of Neurology, Herford Hospital, Herford, Germany., Bayas A; Department of Neurology, Medical Faculty, University of Augsburg, Augsburg, Germany., Zettl UK; Department of Neurology, University of Rostock, Rostock, Germany., Lauenstein AS; Department of Neurology, DKD Helios Hospital Wiesbaden, Wiesbaden, Germany., Yalachkov Y; Department of Neurology, Goethe-University Frankfurt, University Medicine, Frankfurt am Main, Germany., Etgen T; Department of Neurology, Klinikum Traunstein, Traunstein, Germany., Kaste M; Department of Neurology, Nordwest-Krankenhaus Sanderbusch, Sanderbusch, Germany., Luessi F; Department of Neurology, University of Mainz, Mainz, Germany., Gingele S; Department of Neurology, Hannover Medical School, Hannover, Germany., Passoke S; Department of Neurology, Hannover Medical School, Hannover, Germany., Weber MS; Department of Neurology, University of Göttingen, Göttingen, Germany., Sieb JP; Department of Neurology, Helios Hanseklinikum Stralsund, Stralsund, Germany., Haarmann A; Department of Neurology, University of Würzburg, Würzburg, Germany., Oschmann P; Department of Neurology, Klinikum Bayreuth, Bayreuth, Germany., Rothhammer V; Department of Neurology, FAU Erlangen-Nuremberg, Erlangen, Germany., Geis C; Department of Neurology, University of Jena, Jena, Germany., Kowarik MC; Department of Neurology & Stroke and Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany., Kern P; Department of Neurology, Asklepios Expert Clinic Teupitz, Teupitz, Germany., Grothe M; Department of Neurology, University of Greifswald, Greifswald, Germany., Stephanik H; Department of Neurology, University of Magdeburg, Magdeburg, Germany., Angstwurm K; Department of Neurology, University of Regensburg, Regensburg, Germany., Hoffmann F; Department of Neurology, Hospital Martha-Maria, Halle, Germany., Wallwitz U; Department of Neurology, Hospital Martha-Maria, Halle, Germany., Wildemann B; Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany., Jarius S; Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany., Stellmann JP; Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Germany.; CEMEREM, APHM, Hôspital de la Timone, Marseille, France.; CRMBM, Aix Marseille Univ, CNRS, Marseille, France., Pakeerathan T; Department of Neurology, St.Josef Hospital, Ruhr University Bochum, Bochum, Germany., Schwake C; Department of Neurology, St.Josef Hospital, Ruhr University Bochum, Bochum, Germany., Ayzenberg I; Department of Neurology, St.Josef Hospital, Ruhr University Bochum, Bochum, Germany., Kleiter I; Department of Neurology, St.Josef Hospital, Ruhr University Bochum, Bochum, Germany.; Marianne-Strauss-Klinik, Behandlungszentrum für Multiple Sklerose Kranke, Berg, Germany., Fischer K; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Aktas O; Department of Neurology, Herford Hospital, Herford, Germany., Ringelstein M; Department of Neurology, Herford Hospital, Herford, Germany.; Department of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Häußler V; Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Germany., Trebst C; Department of Neurology, Hannover Medical School, Hannover, Germany., Hümmert MW; Department of Neurology, Hannover Medical School, Hannover, Germany.
Source: Frontiers in immunology [Front Immunol] 2025 Apr 11; Vol. 16, pp. 1575613. Date of Electronic Publication: 2025 Apr 11 (Print Publication: 2025).
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study).
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  Data: <searchLink fieldCode="AU" term="%22Kretschmer+JR%22">Kretschmer JR</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Tkachenko+D%22">Tkachenko D</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Kümpfel+T%22">Kümpfel T</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Havla+J%22">Havla J</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Engels+D%22">Engels D</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Paul+F%22">Paul F</searchLink>; Department of Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.; 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      – BibEntity:
          Dates:
            – D: 11
              M: 04
              Text: 2025 Apr 11
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1664-3224
          Numbering:
            – Type: volume
              Value: 16
          Titles:
            – TitleFull: Frontiers in immunology
              Type: main
ResultId 1