ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways.

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Title: ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways.
Authors: Tang Z; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China., Wang XL; Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, P. R. China., Deng YX; Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, P. R. China., Xiao Y; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China., Xu JW; Guizhou Province Key Laboratory of Regenerative Medicine, Guiyang, P. R. China., Wang L; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China., Qi XL; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China. xlq@gmc.edu.cn.
Source: Cell biochemistry and biophysics [Cell Biochem Biophys] 2025 Sep; Vol. 83 (3), pp. 3665-3676. Date of Electronic Publication: 2025 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE
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  Data: ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways.
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  Data: <searchLink fieldCode="AU" term="%22Tang+Z%22">Tang Z</searchLink>; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+XL%22">Wang XL</searchLink>; Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, P. R. China.<br /><searchLink fieldCode="AU" term="%22Deng+YX%22">Deng YX</searchLink>; Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, P. R. China.<br /><searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink>; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China.<br /><searchLink fieldCode="AU" term="%22Xu+JW%22">Xu JW</searchLink>; Guizhou Province Key Laboratory of Regenerative Medicine, Guiyang, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China.<br /><searchLink fieldCode="AU" term="%22Qi+XL%22">Qi XL</searchLink>; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, P. R. China. xlq@gmc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229701934%22">Cell biochemistry and biophysics</searchLink> [Cell Biochem Biophys] 2025 Sep; Vol. 83 (3), pp. 3665-3676. <i>Date of Electronic Publication: </i>2025 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Humana+Press%22">Humana Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9701934 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-0283 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210859195%22">10859195 </searchLink><i>NLM ISO Abbreviation: </i>Cell Biochem Biophys <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s12013-025-01745-y
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      – TitleFull: ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways.
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              Text: 2025 Sep
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