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Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.

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Title: Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.
Authors: Marasco M; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Kumar D; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Garcia Borrego S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Seale T; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Maddalena G; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Oncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy., Mezzadra R; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Belanger K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg-Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Cole S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Perez B; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg-Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Luan W; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Mukherjee R; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Aricescu I; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Markov V; Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Zhu Y; Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Arena S; Department of Oncology, University of Torino, Candiolo (TO), Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy., Bardelli A; IFOM ETS, The AIRC Institute of Molecular Oncology, Milano, Italy.; Department of Oncology, Molecular Biotechnology Center, University of Torino, Torino, Italy., de Stanchina E; Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Lowe SW; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Burkhart RA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Division of Hepatobiliary and Pancreatic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zimmerman JW; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg-Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Yaeger R; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Kopetz SE; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rosen N; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Misale S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Source: Cancer discovery [Cancer Discov] 2025 Jul 03; Vol. 15 (7), pp. 1392-1409.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
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  Data: Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.
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  Data: <searchLink fieldCode="AU" term="%22Marasco+M%22">Marasco M</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Kumar+D%22">Kumar D</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Garcia+Borrego+S%22">Garcia Borrego S</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Seale+T%22">Seale T</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Maddalena+G%22">Maddalena G</searchLink>; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Oncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Mezzadra+R%22">Mezzadra R</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Belanger+K%22">Belanger K</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg-Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Cole+S%22">Cole S</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Perez+B%22">Perez B</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg-Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Luan+W%22">Luan W</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Mukherjee+R%22">Mukherjee R</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Aricescu+I%22">Aricescu I</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Markov+V%22">Markov V</searchLink>; Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Arena+S%22">Arena S</searchLink>; Department of Oncology, University of Torino, Candiolo (TO), Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Bardelli+A%22">Bardelli A</searchLink>; IFOM ETS, The AIRC Institute of Molecular Oncology, Milano, Italy.; Department of Oncology, Molecular Biotechnology Center, University of Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Burkhart+RA%22">Burkhart RA</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Division of Hepatobiliary and Pancreatic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Zimmerman+JW%22">Zimmerman JW</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg-Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Yaeger+R%22">Yaeger R</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Kopetz+SE%22">Kopetz SE</searchLink>; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Rosen+N%22">Rosen N</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Misale+S%22">Misale S</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101561693 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2159-8290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221598274%22">21598274 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Discov <i>Subsets: </i>MEDLINE
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