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Mucosal and Systemic Antibody Responses After Boosting With a Bivalent Messenger RNA Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine.

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Title: Mucosal and Systemic Antibody Responses After Boosting With a Bivalent Messenger RNA Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine.
Authors: Atmar RL; Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Lyke KE; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Posavad CM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Deming ME; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Brady RC; Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Dobrzynski D; Division of Infectious Diseases, Department of Medicine, University of Rochester, Rochester, New York, USA., Edupuganti S; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Mulligan MJ; New York University Langone Vaccine Center and Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA., Rupp RE; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA., Rostad CA; Department of Pediatrics and Center for Childhood Infections and Vaccines, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Jackson LA; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA., Martin JM; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Shriver MC; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Rajakumar K; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Coler RN; Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA., El Sahly HM; Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Kottkamp AC; New York University Langone Vaccine Center and Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA., Branche AR; Division of Infectious Diseases, Department of Medicine, University of Rochester, Rochester, New York, USA., Frenck RW; Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Johnston C; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA., Babu TM; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA., Bäcker M; New York University Langone Hospital-Long Island Vaccine Center Research Clinic and Division of Infectious Disease, Department of Medicine, New York University Grossman Long Island School of Medicine, Mineola, New York, USA., Archer JI; FHI, Durham, North Carolina, USA., Crandon S; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Nakamura A; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Nayak SU; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Szydlo D; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Dominguez Islas CP; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Brown ER; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., O'Connell SE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Montefiori DC; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Eaton A; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Neuzil KM; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Stephens DS; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Beigel JH; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Pasetti M; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Roberts PC; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Source: The Journal of infectious diseases [J Infect Dis] 2025 Oct 15; Vol. 232 (4), pp. 971-981.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mucosal and Systemic Antibody Responses After Boosting With a Bivalent Messenger RNA Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine.
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Division of Infectious Diseases, Department of Medicine, University of Rochester, Rochester, New York, USA.<br /><searchLink fieldCode="AU" term="%22Edupuganti+S%22">Edupuganti S</searchLink>; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Mulligan+MJ%22">Mulligan MJ</searchLink>; New York University Langone Vaccine Center and Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rupp+RE%22">Rupp RE</searchLink>; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Rostad+CA%22">Rostad CA</searchLink>; Department of Pediatrics and Center for Childhood Infections and Vaccines, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+LA%22">Jackson LA</searchLink>; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Martin+JM%22">Martin JM</searchLink>; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Shriver+MC%22">Shriver MC</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Rajakumar+K%22">Rajakumar K</searchLink>; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Coler+RN%22">Coler RN</searchLink>; Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22El+Sahly+HM%22">El Sahly HM</searchLink>; Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Kottkamp+AC%22">Kottkamp AC</searchLink>; New York University Langone Vaccine Center and Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Branche+AR%22">Branche AR</searchLink>; Division of Infectious Diseases, Department of Medicine, University of Rochester, Rochester, New York, USA.<br /><searchLink fieldCode="AU" term="%22Frenck+RW%22">Frenck RW</searchLink>; Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Johnston+C%22">Johnston C</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Babu+TM%22">Babu TM</searchLink>; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Bäcker+M%22">Bäcker M</searchLink>; New York University Langone Hospital-Long Island Vaccine Center Research Clinic and Division of Infectious Disease, Department of Medicine, New York University Grossman Long Island School of Medicine, Mineola, New York, USA.<br /><searchLink fieldCode="AU" term="%22Archer+JI%22">Archer JI</searchLink>; FHI, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Crandon+S%22">Crandon S</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Nakamura+A%22">Nakamura A</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Nayak+SU%22">Nayak SU</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Szydlo+D%22">Szydlo D</searchLink>; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Dominguez+Islas+CP%22">Dominguez Islas CP</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Brown+ER%22">Brown ER</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22O'Connell+SE%22">O'Connell SE</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Montefiori+DC%22">Montefiori DC</searchLink>; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Eaton+A%22">Eaton A</searchLink>; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Neuzil+KM%22">Neuzil KM</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Stephens+DS%22">Stephens DS</searchLink>; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Beigel+JH%22">Beigel JH</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Pasetti+M%22">Pasetti M</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+PC%22">Roberts PC</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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