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A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma.

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Title: A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma.
Authors: Broderick C; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, New York, New York., Mezzadra R; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Sisso EM; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Mbuga F; Revolution Medicines, Redwood City, California., Raghulan R; Revolution Medicines, Redwood City, California., Chaves-Perez A; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Kulick A; Anti-tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Jiang L; Revolution Medicines, Redwood City, California., Jiang J; Revolution Medicines, Redwood City, California., Ho YJ; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Simon J; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Rosiek E; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, New York., Chan E; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, New York., Filliol A; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Chaligne R; Single Cell Analytics Innovation Lab, Memorial Sloan Kettering Cancer Center, New York, New York., de Stanchina E; Anti-tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Pechuan-Jorge X; Revolution Medicines, Redwood City, California., Schietinger A; Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York., Singh M; Revolution Medicines, Redwood City, California., Lowe SW; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.; Howard Hughes Medical Institute, Chevy Chase, Maryland.
Source: Cancer discovery [Cancer Discov] 2025 Aug 04; Vol. 15 (8), pp. 1717-1739.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
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  Data: A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Broderick+C%22">Broderick C</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, New York, New York.<br /><searchLink fieldCode="AU" term="%22Mezzadra+R%22">Mezzadra R</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Sisso+EM%22">Sisso EM</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Mbuga+F%22">Mbuga F</searchLink>; Revolution Medicines, Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Raghulan+R%22">Raghulan R</searchLink>; Revolution Medicines, Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Chaves-Perez+A%22">Chaves-Perez A</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Kulick+A%22">Kulick A</searchLink>; Anti-tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Revolution Medicines, Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; Revolution Medicines, Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Ho+YJ%22">Ho YJ</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Simon+J%22">Simon J</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Rosiek+E%22">Rosiek E</searchLink>; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chan+E%22">Chan E</searchLink>; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Filliol+A%22">Filliol A</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chaligne+R%22">Chaligne R</searchLink>; Single Cell Analytics Innovation Lab, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Anti-tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Pechuan-Jorge+X%22">Pechuan-Jorge X</searchLink>; Revolution Medicines, Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Schietinger+A%22">Schietinger A</searchLink>; Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Revolution Medicines, Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.; Howard Hughes Medical Institute, Chevy Chase, Maryland.
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