A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma.
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| Title: | A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma. |
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| Authors: | Broderick C; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, New York, New York., Mezzadra R; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Sisso EM; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Mbuga F; Revolution Medicines, Redwood City, California., Raghulan R; Revolution Medicines, Redwood City, California., Chaves-Perez A; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Kulick A; Anti-tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Jiang L; Revolution Medicines, Redwood City, California., Jiang J; Revolution Medicines, Redwood City, California., Ho YJ; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Simon J; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Rosiek E; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, New York., Chan E; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, New York., Filliol A; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Chaligne R; Single Cell Analytics Innovation Lab, Memorial Sloan Kettering Cancer Center, New York, New York., de Stanchina E; Anti-tumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Pechuan-Jorge X; Revolution Medicines, Redwood City, California., Schietinger A; Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York., Singh M; Revolution Medicines, Redwood City, California., Lowe SW; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.; Howard Hughes Medical Institute, Chevy Chase, Maryland. |
| Source: | Cancer discovery [Cancer Discov] 2025 Aug 04; Vol. 15 (8), pp. 1717-1739. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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