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Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan.

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Title: Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan.
Authors: Farrag M; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt., Aljuhani R; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20057, United States.; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States., Benicky J; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States.; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, United States., Al Ahmed H; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States., Misra SK; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States., Mishra SK; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Department of Biomedical Engineering, University of Mississippi, University, MS 38677, United States., Sharp JS; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States.; Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, United States., Doerksen RJ; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States., Goldman R; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20057, United States.; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States.; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, United States., Pomin VH; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States.
Source: Glycobiology [Glycobiology] 2025 Apr 23; Vol. 35 (6).
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9104124 Publication Model: Print Cited Medium: Internet ISSN: 1460-2423 (Electronic) Linking ISSN: 09596658 NLM ISO Abbreviation: Glycobiology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan.
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  Data: <searchLink fieldCode="AU" term="%22Farrag+M%22">Farrag M</searchLink>; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt.<br /><searchLink fieldCode="AU" term="%22Aljuhani+R%22">Aljuhani R</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20057, United States.; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States.<br /><searchLink fieldCode="AU" term="%22Benicky+J%22">Benicky J</searchLink>; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States.; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, United States.<br /><searchLink fieldCode="AU" term="%22Al+Ahmed+H%22">Al Ahmed H</searchLink>; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.<br /><searchLink fieldCode="AU" term="%22Misra+SK%22">Misra SK</searchLink>; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.<br /><searchLink fieldCode="AU" term="%22Mishra+SK%22">Mishra SK</searchLink>; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Department of Biomedical Engineering, University of Mississippi, University, MS 38677, United States.<br /><searchLink fieldCode="AU" term="%22Sharp+JS%22">Sharp JS</searchLink>; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States.; Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, United States.<br /><searchLink fieldCode="AU" term="%22Doerksen+RJ%22">Doerksen RJ</searchLink>; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States.<br /><searchLink fieldCode="AU" term="%22Goldman+R%22">Goldman R</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20057, United States.; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States.; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, United States.<br /><searchLink fieldCode="AU" term="%22Pomin+VH%22">Pomin VH</searchLink>; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States.
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              Text: 2025 Apr 23
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