Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan.
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| Title: | Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan. |
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| Authors: | Farrag M; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt., Aljuhani R; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20057, United States.; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States., Benicky J; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States.; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, United States., Al Ahmed H; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States., Misra SK; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States., Mishra SK; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Department of Biomedical Engineering, University of Mississippi, University, MS 38677, United States., Sharp JS; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States.; Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, United States., Doerksen RJ; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States., Goldman R; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20057, United States.; Clinical and Translational Glycoscience Research Center, Georgetown University, Washington, DC 20057, United States.; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, United States., Pomin VH; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.; Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, United States. |
| Source: | Glycobiology [Glycobiology] 2025 Apr 23; Vol. 35 (6). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9104124 Publication Model: Print Cited Medium: Internet ISSN: 1460-2423 (Electronic) Linking ISSN: 09596658 NLM ISO Abbreviation: Glycobiology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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