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PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.

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Title: PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.
Authors: Yadav M; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada., AlQazzaz MA; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada., Ciamponi FE; Center for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP), Campinas 13083-872, Brazil., Ho JC; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada., Maron MI; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States., Sababi AM; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S3E1, Canada., MacLeod G; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada., Ahmadi M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S3M2, Canada., Bullivant G; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada., Tano V; Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore., Langley SR; Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore.; School of Biosciences, Cardiff University, Cardiff CF103AX, United Kingdom., Sánchez-Osuna M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C3J7, Canada., Sachamitr P; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada., Kushida M; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada., Bardile CF; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Djavad Mowafaghian Centre for Brain Health, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z4H4, Canada., Pouladi MA; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Djavad Mowafaghian Centre for Brain Health, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z4H4, Canada., Kurtz R; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N3Z5, Canada., Richards L; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada., Pugh T; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.; Ontario Institute for Cancer Research, University Health Network, Toronto, ON, M5G0A3, Canada., Tyers M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C3J7, Canada., Angers S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S3M2, Canada., Dirks PB; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, M5S1A8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S1A8, Canada., Bader GD; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S3E1, Canada.; Lunenfeld-Tanenbaum Research Institut e, Sinai Health System, Toronto, ON, M5G1X5, Canada.; Department of Computer Science, University of Toronto, ON, M5S3E1, Canada., Truant R; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N3Z5, Canada., Massirer KB; Center for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP), Campinas 13083-872, Brazil., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5G1L7, Canada., Shechter D; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States., Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S3M2, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5G1L7, Canada., Arrowsmith CH; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada., Prinos P; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Apr 22; Vol. 53 (8).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
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  Data: PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.
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  Data: <searchLink fieldCode="AU" term="%22Yadav+M%22">Yadav M</searchLink>; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22AlQazzaz+MA%22">AlQazzaz MA</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Ciamponi+FE%22">Ciamponi FE</searchLink>; Center for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP), Campinas 13083-872, Brazil.<br /><searchLink fieldCode="AU" term="%22Ho+JC%22">Ho JC</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Maron+MI%22">Maron MI</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States.<br /><searchLink fieldCode="AU" term="%22Sababi+AM%22">Sababi AM</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S3E1, Canada.<br /><searchLink fieldCode="AU" term="%22MacLeod+G%22">MacLeod G</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Ahmadi+M%22">Ahmadi M</searchLink>; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S3M2, Canada.<br /><searchLink fieldCode="AU" term="%22Bullivant+G%22">Bullivant G</searchLink>; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Tano+V%22">Tano V</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore.<br /><searchLink fieldCode="AU" term="%22Langley+SR%22">Langley SR</searchLink>; 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Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Djavad Mowafaghian Centre for Brain Health, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z4H4, Canada.<br /><searchLink fieldCode="AU" term="%22Kurtz+R%22">Kurtz R</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Richards+L%22">Richards L</searchLink>; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Pugh+T%22">Pugh T</searchLink>; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.; Ontario Institute for Cancer Research, University Health Network, Toronto, ON, M5G0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Angers+S%22">Angers S</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S3M2, Canada.<br /><searchLink fieldCode="AU" term="%22Dirks+PB%22">Dirks PB</searchLink>; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, M5S1A8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Bader+GD%22">Bader GD</searchLink>; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S3E1, Canada.; Lunenfeld-Tanenbaum Research Institut e, Sinai Health System, Toronto, ON, M5G1X5, Canada.; Department of Computer Science, University of Toronto, ON, M5S3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Truant+R%22">Truant R</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Massirer+KB%22">Massirer KB</searchLink>; Center for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP), Campinas 13083-872, Brazil.<br /><searchLink fieldCode="AU" term="%22Barsyte-Lovejoy+D%22">Barsyte-Lovejoy D</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Shechter+D%22">Shechter D</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States.<br /><searchLink fieldCode="AU" term="%22Harding+RJ%22">Harding RJ</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S3M2, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Arrowsmith+CH%22">Arrowsmith CH</searchLink>; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.; Princess Margaret Cancer Centre, U niversity Health Network, Toronto, ON, M5G1L7, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Prinos+P%22">Prinos P</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.
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