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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies.

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Title: Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies.
Authors: Yassin M; National Center for Cancer Care and Research, Doha, Qatar. Electronic address: yassinmoha@gmail.com., Minniti C; Montefiore Medical Center, Albert Einstein College of Medicine, New York, United States., Shah N; Duke University Medical Center, Durham, United States., Alkindi S; Sultan Qaboos University Hospital, Seeb, Oman., Ata F; Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar. Electronic address: FAta@hamad.qa., Qari M; King Abdulaziz University, Jeddah, Saudi Arabia., Al Zayed A; Qatif Central Hospital, Al Qatif, Saudi Arabia., Altooq J; Hereditary Blood Disorder Center, Manama, Bahrain., Al Rasheed M; Adan Hospital, Hadiya, Kuwait., Capellini MD; University of Milan, Milan, Italy.
Source: Blood reviews [Blood Rev] 2025 Aug; Vol. 73, pp. 101298. Date of Electronic Publication: 2025 Apr 25.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8708558 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1681 (Electronic) Linking ISSN: 0268960X NLM ISO Abbreviation: Blood Rev Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies.
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  Data: <searchLink fieldCode="AU" term="%22Yassin+M%22">Yassin M</searchLink>; National Center for Cancer Care and Research, Doha, Qatar. Electronic address: yassinmoha@gmail.com.<br /><searchLink fieldCode="AU" term="%22Minniti+C%22">Minniti C</searchLink>; Montefiore Medical Center, Albert Einstein College of Medicine, New York, United States.<br /><searchLink fieldCode="AU" term="%22Shah+N%22">Shah N</searchLink>; Duke University Medical Center, Durham, United States.<br /><searchLink fieldCode="AU" term="%22Alkindi+S%22">Alkindi S</searchLink>; Sultan Qaboos University Hospital, Seeb, Oman.<br /><searchLink fieldCode="AU" term="%22Ata+F%22">Ata F</searchLink>; Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar. Electronic address: FAta@hamad.qa.<br /><searchLink fieldCode="AU" term="%22Qari+M%22">Qari M</searchLink>; King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al+Zayed+A%22">Al Zayed A</searchLink>; Qatif Central Hospital, Al Qatif, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Altooq+J%22">Altooq J</searchLink>; Hereditary Blood Disorder Center, Manama, Bahrain.<br /><searchLink fieldCode="AU" term="%22Al+Rasheed+M%22">Al Rasheed M</searchLink>; Adan Hospital, Hadiya, Kuwait.<br /><searchLink fieldCode="AU" term="%22Capellini+MD%22">Capellini MD</searchLink>; University of Milan, Milan, Italy.
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  Data: <searchLink fieldCode="JN" term="%228708558%22">Blood reviews</searchLink> [Blood Rev] 2025 Aug; Vol. 73, pp. 101298. <i>Date of Electronic Publication: </i>2025 Apr 25.
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        Value: 10.1016/j.blre.2025.101298
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        Text: English
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        StartPage: 101298
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      – TitleFull: Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies.
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              Text: 2025 Aug
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