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Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures.

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Title: Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures.
Authors: McGeachan RI; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.; The Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Meftah S; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Taylor LW; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Catterson JH; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Negro D; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Bonthron C; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Holt K; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Tulloch J; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Rose JL; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Gobbo F; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Chang YY; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Elliott J; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., McLay L; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., King D; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Liaquat I; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK., Spires-Jones TL; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Booker SA; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK., Brennan PM; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK.; Translational Neurosurgery, The Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Cancer Research UK Brain Tumour Centre of Excellence, CRUK Edinburgh Centre, The University of Edinburgh, Edinburgh, UK., Durrant CS; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.
Source: Nature communications [Nat Commun] 2025 Apr 30; Vol. 16 (1), pp. 3753. Date of Electronic Publication: 2025 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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