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Problems With Noninferiority Designs in PTSD Treatment Research: Losing Signal to Noise.

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Title: Problems With Noninferiority Designs in PTSD Treatment Research: Losing Signal to Noise.
Authors: Rauch SAM; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk)., Kim HM; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk)., Acierno R; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk)., Tuerk PW; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk)., Rothbaum BO; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk).
Source: The American journal of psychiatry [Am J Psychiatry] 2025 May 01; Vol. 182 (5), pp. 421-423.
Publication Type: Journal Article
Journal Info: Publisher: American Psychiatric Association Country of Publication: United States NLM ID: 0370512 Publication Model: Print Cited Medium: Internet ISSN: 1535-7228 (Electronic) Linking ISSN: 0002953X NLM ISO Abbreviation: Am J Psychiatry Subsets: MEDLINE; In Process
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  Data: Problems With Noninferiority Designs in PTSD Treatment Research: Losing Signal to Noise.
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  Data: <searchLink fieldCode="AU" term="%22Rauch+SAM%22">Rauch SAM</searchLink>; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk).<br /><searchLink fieldCode="AU" term="%22Kim+HM%22">Kim HM</searchLink>; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk).<br /><searchLink fieldCode="AU" term="%22Acierno+R%22">Acierno R</searchLink>; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk).<br /><searchLink fieldCode="AU" term="%22Tuerk+PW%22">Tuerk PW</searchLink>; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk).<br /><searchLink fieldCode="AU" term="%22Rothbaum+BO%22">Rothbaum BO</searchLink>; Atlanta VA Medical Center, Decatur, Ga. (Rauch); Emory University School of Medicine, Atlanta (Rauch, Rothbaum); VA Ann Arbor Healthcare System, Ann Arbor, Mich. (Kim); University of Michigan, Consulting for Statistics, Computing and Analytics Research, Ann Arbor, Mich. (Kim); Ralph H. Johnson VA Health Care System, Charleston, S.C. (Acierno); University of Texas Health Science Center at Houston, Houston (Acierno); University of Virginia, Sheila Johnson Center for Clinical Services, Charlottesville (Tuerk).
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