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Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.

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Title: Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Authors: Sakuma I; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan., Gaspar RC; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Nasiri AR; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Dufour S; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Kahn M; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Zheng J; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., LaMoia TE; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Guerra MT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Taki Y; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan., Kawashima Y; Department of Applied Genomics, Kazusa deoxyribonucleic acid Research Institute, Chiba 292-0818, Japan., Yimlamai D; Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520., Perelis M; Ionis Pharmaceuticals, Carlsbad, CA 92010., Vatner DF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Petersen KF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520., Huttasch M; Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany., Knebel B; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany.; Institute for Pathobiochemistry, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany., Kahl S; Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany., Roden M; Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany., Samuel VT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; West Haven Veterans Affairs Medical Center, West Haven, CT 06516-2770., Tanaka T; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan., Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.; HHMI, Chevy Chase, MD 20815.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 May 06; Vol. 122 (18), pp. e2502978122. Date of Electronic Publication: 2025 May 01.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
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  Data: <searchLink fieldCode="AU" term="%22Sakuma+I%22">Sakuma I</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Gaspar+RC%22">Gaspar RC</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Nasiri+AR%22">Nasiri AR</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Dufour+S%22">Dufour S</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Kahn+M%22">Kahn M</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22LaMoia+TE%22">LaMoia TE</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Guerra+MT%22">Guerra MT</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Taki+Y%22">Taki Y</searchLink>; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Kawashima+Y%22">Kawashima Y</searchLink>; Department of Applied Genomics, Kazusa deoxyribonucleic acid Research Institute, Chiba 292-0818, Japan.<br /><searchLink fieldCode="AU" term="%22Yimlamai+D%22">Yimlamai D</searchLink>; Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Perelis+M%22">Perelis M</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA 92010.<br /><searchLink fieldCode="AU" term="%22Vatner+DF%22">Vatner DF</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Petersen+KF%22">Petersen KF</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Huttasch+M%22">Huttasch M</searchLink>; Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany.<br /><searchLink fieldCode="AU" term="%22Knebel+B%22">Knebel B</searchLink>; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany.; Institute for Pathobiochemistry, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.<br /><searchLink fieldCode="AU" term="%22Kahl+S%22">Kahl S</searchLink>; Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.<br /><searchLink fieldCode="AU" term="%22Roden+M%22">Roden M</searchLink>; Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.; German Center for Diabetes Research (Deutsche Zentrum für Diabetesforschung e.V.), Partner Düsseldorf, München-Neuherberg 85764, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.<br /><searchLink fieldCode="AU" term="%22Samuel+VT%22">Samuel VT</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; West Haven Veterans Affairs Medical Center, West Haven, CT 06516-2770.<br /><searchLink fieldCode="AU" term="%22Tanaka+T%22">Tanaka T</searchLink>; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Shulman+GI%22">Shulman GI</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.; HHMI, Chevy Chase, MD 20815.
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