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Aberrant basal cell clonal dynamics shape early lung carcinogenesis.

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Title: Aberrant basal cell clonal dynamics shape early lung carcinogenesis.
Authors: Gómez-López S; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Alhendi ASN; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Przybilla MJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Bordeu I; Departamento de Física, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile., Whiteman ZE; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Butler T; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Rouhani MJ; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Kalinke L; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Uddin I; Cancer Research UK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK.; Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK., Otter KEJ; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Chandrasekharan DP; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Lebrusant-Fernandez M; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, University College London, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Shurr AYL; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, University College London, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Durrenberger PF; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals NHS Trust, London, UK., Falzon M; Department of Cellular Pathology, University College London Hospitals NHS Trust, London, UK., Reading JL; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, University College London, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Martincorena I; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Simons BD; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Janes SM; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.; University College London Hospitals NHS Trust, London, UK.
Source: Science (New York, N.Y.) [Science] 2025 Jun 12; Vol. 388 (6752), pp. eads9145. Date of Electronic Publication: 2025 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Aberrant basal cell clonal dynamics shape early lung carcinogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Gómez-López+S%22">Gómez-López S</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Alhendi+ASN%22">Alhendi ASN</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Przybilla+MJ%22">Przybilla MJ</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Bordeu+I%22">Bordeu I</searchLink>; Departamento de Física, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Whiteman+ZE%22">Whiteman ZE</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Butler+T%22">Butler T</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Rouhani+MJ%22">Rouhani MJ</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kalinke+L%22">Kalinke L</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Uddin+I%22">Uddin I</searchLink>; Cancer Research UK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK.; Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Otter+KEJ%22">Otter KEJ</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chandrasekharan+DP%22">Chandrasekharan DP</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lebrusant-Fernandez+M%22">Lebrusant-Fernandez M</searchLink>; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, University College London, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Shurr+AYL%22">Shurr AYL</searchLink>; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, University College London, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Durrenberger+PF%22">Durrenberger PF</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Moore+DA%22">Moore DA</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Falzon+M%22">Falzon M</searchLink>; Department of Cellular Pathology, University College London Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Reading+JL%22">Reading JL</searchLink>; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, University College London, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Martincorena+I%22">Martincorena I</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Simons+BD%22">Simons BD</searchLink>; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Janes+SM%22">Janes SM</searchLink>; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.; University College London Hospitals NHS Trust, London, UK.
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