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Dialkyloxyphenyl hybrids as PDE4B inhibitors: Design, synthesis, in vitro/in vivo anti-inflammatory activity and in silico insights.

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Title: Dialkyloxyphenyl hybrids as PDE4B inhibitors: Design, synthesis, in vitro/in vivo anti-inflammatory activity and in silico insights.
Authors: Almatary AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt. Electronic address: Aelmatary@horus.edu.eg., Salem MSH; SANKEN, The University of Osaka, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, 4.5 Km the Ring Road, Ismailia 41522, Egypt., Elnagar MR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11823, Egypt; Department of Pharmacology, College of Pharmacy, The Islamic University, Najaf 54001, Iraq., Aboutaleb MH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt., Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Hamdi A; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Mansoura University, Mansoura, Egypt. Electronic address: abdelrahmanhamdi2012@yahoo.com., El-Sayed MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Mansoura University, Mansoura, Egypt.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Jul 01; Vol. 161, pp. 108511. Date of Electronic Publication: 2025 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Almatary+AM%22">Almatary AM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt. Electronic address: Aelmatary@horus.edu.eg.<br /><searchLink fieldCode="AU" term="%22Salem+MSH%22">Salem MSH</searchLink>; SANKEN, The University of Osaka, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, 4.5 Km the Ring Road, Ismailia 41522, Egypt.<br /><searchLink fieldCode="AU" term="%22Elnagar+MR%22">Elnagar MR</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11823, Egypt; Department of Pharmacology, College of Pharmacy, The Islamic University, Najaf 54001, Iraq.<br /><searchLink fieldCode="AU" term="%22Aboutaleb+MH%22">Aboutaleb MH</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Ibrahim+TS%22">Ibrahim TS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.<br /><searchLink fieldCode="AU" term="%22Hamdi+A%22">Hamdi A</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Mansoura University, Mansoura, Egypt. Electronic address: abdelrahmanhamdi2012@yahoo.com.<br /><searchLink fieldCode="AU" term="%22El-Sayed+MA%22">El-Sayed MA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Mansoura University, Mansoura, Egypt.
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              Text: 2025 Jul 01
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