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Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial.

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Title: Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial.
Authors: Knowler WC; Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA. Electronic address: dppmail@bsc.gwu.edu., Doherty L; Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA., Edelstein SL; Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA., Bennett PH; National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA., Dabelea D; Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Hoskin M; National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA., Kahn SE; Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA., Kalyani RR; Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kim C; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Pi-Sunyer FX; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA., Raghavan S; Department of Medicine, VA Eastern Colorado Health Care System and University of Colorado School of Medicine, Aurora, CO, USA., Shah VO; School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA., Temprosa M; Department of Biostatistics and Bioinformatics and Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA., Venditti EM; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nathan DM; Diabetes Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Corporate Authors: DPP/DPPOS Research Group
Source: The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2025 Jun; Vol. 13 (6), pp. 469-481. Date of Electronic Publication: 2025 Apr 28.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
Journal Info: Publisher: The Lancet, Diabetes & Endocrinology Country of Publication: England NLM ID: 101618821 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-8595 (Electronic) Linking ISSN: 22138587 NLM ISO Abbreviation: Lancet Diabetes Endocrinol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Knowler+WC%22">Knowler WC</searchLink>; Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA. Electronic address: dppmail@bsc.gwu.edu.<br /><searchLink fieldCode="AU" term="%22Doherty+L%22">Doherty L</searchLink>; Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Edelstein+SL%22">Edelstein SL</searchLink>; Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+PH%22">Bennett PH</searchLink>; National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Dabelea+D%22">Dabelea D</searchLink>; Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Hoskin+M%22">Hoskin M</searchLink>; National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+SE%22">Kahn SE</searchLink>; Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kalyani+RR%22">Kalyani RR</searchLink>; Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kim+C%22">Kim C</searchLink>; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pi-Sunyer+FX%22">Pi-Sunyer FX</searchLink>; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Raghavan+S%22">Raghavan S</searchLink>; Department of Medicine, VA Eastern Colorado Health Care System and University of Colorado School of Medicine, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Shah+VO%22">Shah VO</searchLink>; School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.<br /><searchLink fieldCode="AU" term="%22Temprosa+M%22">Temprosa M</searchLink>; Department of Biostatistics and Bioinformatics and Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Venditti+EM%22">Venditti EM</searchLink>; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nathan+DM%22">Nathan DM</searchLink>; Diabetes Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101618821%22">The lancet. Diabetes & endocrinology</searchLink> [Lancet Diabetes Endocrinol] 2025 Jun; Vol. 13 (6), pp. 469-481. <i>Date of Electronic Publication: </i>2025 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22The+Lancet%2C+Diabetes+%26+Endocrinology%22">The Lancet, Diabetes & Endocrinology </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101618821 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-8595 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222138587%22">22138587 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Diabetes Endocrinol <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun
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