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Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's disease.

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Title: Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's disease.
Authors: Tortolani D; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Veterinary Medicine, University of Teramo, Teramo, Italy., Decandia D; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Psychology, University Sapienza of Rome, Rome, Italy., Giacovazzo G; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Veterinary Medicine, University of Teramo, Teramo, Italy., Scipioni L; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Panuccio A; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Psychology, University Sapienza of Rome, Rome, Italy., Ciaramellano F; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy., Eugelio F; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Fanti F; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Latagliata EC; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy., La Barbera L; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Cutuli D; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Psychology, University Sapienza of Rome, Rome, Italy., Compagnone D; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., D'Amelio M; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Coccurello R; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Institute for Complex Systems (ISC), National Council of Research (CNR), Rome, Italy., Oddi S; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Veterinary Medicine, University of Teramo, Teramo, Italy., Petrosini L; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy., Maccarrone M; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Source: Frontiers in cellular neuroscience [Front Cell Neurosci] 2025 Apr 17; Vol. 19, pp. 1571428. Date of Electronic Publication: 2025 Apr 17 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Tortolani+D%22">Tortolani D</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Veterinary Medicine, University of Teramo, Teramo, Italy.<br /><searchLink fieldCode="AU" term="%22Decandia+D%22">Decandia D</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Psychology, University Sapienza of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giacovazzo+G%22">Giacovazzo G</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Veterinary Medicine, University of Teramo, Teramo, Italy.<br /><searchLink fieldCode="AU" term="%22Scipioni+L%22">Scipioni L</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Panuccio+A%22">Panuccio A</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Psychology, University Sapienza of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ciaramellano+F%22">Ciaramellano F</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Eugelio+F%22">Eugelio F</searchLink>; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.<br /><searchLink fieldCode="AU" term="%22Fanti+F%22">Fanti F</searchLink>; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.<br /><searchLink fieldCode="AU" term="%22Latagliata+EC%22">Latagliata EC</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22La+Barbera+L%22">La Barbera L</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cutuli+D%22">Cutuli D</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Psychology, University Sapienza of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Compagnone+D%22">Compagnone D</searchLink>; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.<br /><searchLink fieldCode="AU" term="%22D'Amelio+M%22">D'Amelio M</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Coccurello+R%22">Coccurello R</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Institute for Complex Systems (ISC), National Council of Research (CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Oddi+S%22">Oddi S</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Veterinary Medicine, University of Teramo, Teramo, Italy.<br /><searchLink fieldCode="AU" term="%22Petrosini+L%22">Petrosini L</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Maccarrone+M%22">Maccarrone M</searchLink>; European Center for Brain Research, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101477935%22">Frontiers in cellular neuroscience</searchLink> [Front Cell Neurosci] 2025 Apr 17; Vol. 19, pp. 1571428. <i>Date of Electronic Publication: </i>2025 Apr 17 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101477935 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1662-5102 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216625102%22">16625102 </searchLink><i>NLM ISO Abbreviation: </i>Front Cell Neurosci <i>Subsets: </i>PubMed not MEDLINE
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