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A tissue-specific atlas of protein-protein associations enables prioritization of candidate disease genes.

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Title: A tissue-specific atlas of protein-protein associations enables prioritization of candidate disease genes.
Authors: Laman Trip DS; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. lamantrip@imsb.biol.ethz.ch.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. lamantrip@imsb.biol.ethz.ch., van Oostrum M; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Zurich, Switzerland.; Biozentrum, University of Basel, Basel, Switzerland., Memon D; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK., Frommelt F; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Baptista D; Gulbenkian Institute for Molecular Medicine, Oeiras, Portugal., Panneerselvam K; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK., Bradley G; Computational Biology, Functional Genomics, GSK, Stevenage, UK., Licata L; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Hermjakob H; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK., Orchard S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK., Trynka G; Open Targets, Wellcome Genome Campus, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., McDonagh EM; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Fossati A; Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solna, Sweden., Aebersold R; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Gstaiger M; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Wollscheid B; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Zurich, Switzerland., Beltrao P; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. pbeltrao@ethz.ch.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. pbeltrao@ethz.ch.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK. pbeltrao@ethz.ch.; Open Targets, Wellcome Genome Campus, Cambridge, UK. pbeltrao@ethz.ch.; Gulbenkian Institute for Molecular Medicine, Oeiras, Portugal. pbeltrao@ethz.ch.
Source: Nature biotechnology [Nat Biotechnol] 2026 Apr; Vol. 44 (4), pp. 654-667. Date of Electronic Publication: 2025 May 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Laman+Trip+DS%22">Laman Trip DS</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. lamantrip@imsb.biol.ethz.ch.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. lamantrip@imsb.biol.ethz.ch.<br /><searchLink fieldCode="AU" term="%22van+Oostrum+M%22">van Oostrum M</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Zurich, Switzerland.; Biozentrum, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Memon+D%22">Memon D</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Frommelt+F%22">Frommelt F</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Baptista+D%22">Baptista D</searchLink>; Gulbenkian Institute for Molecular Medicine, Oeiras, Portugal.<br /><searchLink fieldCode="AU" term="%22Panneerselvam+K%22">Panneerselvam K</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bradley+G%22">Bradley G</searchLink>; Computational Biology, Functional Genomics, GSK, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Licata+L%22">Licata L</searchLink>; Department of Biology, University of Rome Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Hermjakob+H%22">Hermjakob H</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Orchard+S%22">Orchard S</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Trynka+G%22">Trynka G</searchLink>; Open Targets, Wellcome Genome Campus, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McDonagh+EM%22">McDonagh EM</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; Open Targets, Wellcome Genome Campus, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fossati+A%22">Fossati A</searchLink>; Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Aebersold+R%22">Aebersold R</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gstaiger+M%22">Gstaiger M</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wollscheid+B%22">Wollscheid B</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Beltrao+P%22">Beltrao P</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. pbeltrao@ethz.ch.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. pbeltrao@ethz.ch.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK. pbeltrao@ethz.ch.; Open Targets, Wellcome Genome Campus, Cambridge, UK. pbeltrao@ethz.ch.; Gulbenkian Institute for Molecular Medicine, Oeiras, Portugal. pbeltrao@ethz.ch.
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  Data: <searchLink fieldCode="JN" term="%229604648%22">Nature biotechnology</searchLink> [Nat Biotechnol] 2026 Apr; Vol. 44 (4), pp. 654-667. <i>Date of Electronic Publication: </i>2025 May 02.
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