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NOX4-driven mitochondrial oxidative stress in aging promotes myocardial remodeling and increases susceptibility to ventricular tachyarrhythmia.

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Title: NOX4-driven mitochondrial oxidative stress in aging promotes myocardial remodeling and increases susceptibility to ventricular tachyarrhythmia.
Authors: Mondragon RR; Department of Pharmacology, University of Michigan, 1150 West Medical Center Dr., 2301 Medical Science Research Building III, Ann Arbor, MI, 48109, USA., Wang S; Department of Pharmacology, University of Michigan, 1150 West Medical Center Dr., 2301 Medical Science Research Building III, Ann Arbor, MI, 48109, USA., Stevenson MD; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA., Lozhkin A; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA., Vendrov AE; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA., Isom LL; Department of Pharmacology, University of Michigan, 1150 West Medical Center Dr., 2301 Medical Science Research Building III, Ann Arbor, MI, 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA., Runge MS; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA., Madamanchi NR; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: madamanc@med.umich.edu.
Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Aug 01; Vol. 235, pp. 294-305. Date of Electronic Publication: 2025 May 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mondragon+RR%22">Mondragon RR</searchLink>; Department of Pharmacology, University of Michigan, 1150 West Medical Center Dr., 2301 Medical Science Research Building III, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Pharmacology, University of Michigan, 1150 West Medical Center Dr., 2301 Medical Science Research Building III, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Stevenson+MD%22">Stevenson MD</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Lozhkin+A%22">Lozhkin A</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Vendrov+AE%22">Vendrov AE</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Isom+LL%22">Isom LL</searchLink>; Department of Pharmacology, University of Michigan, 1150 West Medical Center Dr., 2301 Medical Science Research Building III, Ann Arbor, MI, 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Runge+MS%22">Runge MS</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Madamanchi+NR%22">Madamanchi NR</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: madamanc@med.umich.edu.
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