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The anti-diabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer.

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Title: The anti-diabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer.
Authors: Atas E; Department of Pathology, Medical University of Vienna, Vienna, Austria. emine.atas@meduniwien.ac.at.; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, Vienna, Austria. emine.atas@meduniwien.ac.at.; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. emine.atas@meduniwien.ac.at., Berchtold K; University of Vienna, Vienna, Austria., Schlederer M; Department of Pathology, Medical University of Vienna, Vienna, Austria., Prodinger S; University of Vienna, Vienna, Austria., Sternberg F; Department of Biological Sciences and Pathobiology, Unit of Physiology and Biophysics, University of Veterinary Medicine, Vienna, Austria.; Department of Nutritional Science, University of Vienna, Vienna, Austria., Pucci P; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Steel C; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Matthews JD; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., James ER; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Philippe C; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria., Trachtová K; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, Vienna, Austria.; Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic., Moazzami AA; Department of Molecular Sciences, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden., Artamonova N; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria., Melchior F; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria., Redmer T; Unit of Laboratory Animal Pathology, Institute of Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Timelthaler G; Center for Cancer Research, Medical University of Vienna, Vienna, Austria., Pohl EE; Department of Biological Sciences and Pathobiology, Unit of Physiology and Biophysics, University of Veterinary Medicine, Vienna, Austria., Turner SD; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.; Faculty of Medicine, Masaryk University, Brno, Czech Republic., Heidegger I; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria., Krueger M; Institute for Genetics, Cologne Excellence Cluster of Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Resch U; Center of Physiology and Pharmacology, Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria., Kenner L; Department of Pathology, Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Unit of Laboratory Animal Pathology, Institute of Pathology, University of Veterinary Medicine Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Center for Biomarker Research in Medicine GmbH (CBmed), Graz, Austria. lukas.kenner@meduniwien.ac.at.; Department of Molecular Biology, Umeå University, Umea, Sweden. lukas.kenner@meduniwien.ac.at.
Source: Molecular cancer [Mol Cancer] 2025 May 05; Vol. 24 (1), pp. 134. Date of Electronic Publication: 2025 May 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
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  Data: The anti-diabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer.
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  Data: <searchLink fieldCode="AU" term="%22Atas+E%22">Atas E</searchLink>; Department of Pathology, Medical University of Vienna, Vienna, Austria. emine.atas@meduniwien.ac.at.; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, Vienna, Austria. emine.atas@meduniwien.ac.at.; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. emine.atas@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Berchtold+K%22">Berchtold K</searchLink>; University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schlederer+M%22">Schlederer M</searchLink>; Department of Pathology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Prodinger+S%22">Prodinger S</searchLink>; University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Sternberg+F%22">Sternberg F</searchLink>; Department of Biological Sciences and Pathobiology, Unit of Physiology and Biophysics, University of Veterinary Medicine, Vienna, Austria.; Department of Nutritional Science, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pucci+P%22">Pucci P</searchLink>; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Steel+C%22">Steel C</searchLink>; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+JD%22">Matthews JD</searchLink>; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22James+ER%22">James ER</searchLink>; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Philippe+C%22">Philippe C</searchLink>; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Trachtová+K%22">Trachtová K</searchLink>; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, Vienna, Austria.; Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Moazzami+AA%22">Moazzami AA</searchLink>; Department of Molecular Sciences, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Artamonova+N%22">Artamonova N</searchLink>; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Melchior+F%22">Melchior F</searchLink>; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Redmer+T%22">Redmer T</searchLink>; Unit of Laboratory Animal Pathology, Institute of Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Timelthaler+G%22">Timelthaler G</searchLink>; Center for Cancer Research, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pohl+EE%22">Pohl EE</searchLink>; Department of Biological Sciences and Pathobiology, Unit of Physiology and Biophysics, University of Veterinary Medicine, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Turner+SD%22">Turner SD</searchLink>; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.; Faculty of Medicine, Masaryk University, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Heidegger+I%22">Heidegger I</searchLink>; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Krueger+M%22">Krueger M</searchLink>; Institute for Genetics, Cologne Excellence Cluster of Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Resch+U%22">Resch U</searchLink>; Center of Physiology and Pharmacology, Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kenner+L%22">Kenner L</searchLink>; Department of Pathology, Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Unit of Laboratory Animal Pathology, Institute of Pathology, University of Veterinary Medicine Vienna, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Center for Biomarker Research in Medicine GmbH (CBmed), Graz, Austria. lukas.kenner@meduniwien.ac.at.; Department of Molecular Biology, Umeå University, Umea, Sweden. lukas.kenner@meduniwien.ac.at.
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