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Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma.

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Title: Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma.
Authors: Renatino Canevarolo R; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Sudalagunta PR; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Meads MB; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Silva M; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Zhao X; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Magaletti D; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Alugubelli RR; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., DeAvila G; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Persi E; Computational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Maura F; Division of Myeloma, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA., Bell ET; Department of Biological Science, Florida State University, Tallahassee, FL, USA., Bishop RT; Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Cubitt CL; Immune Monitoring Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA., Sansil SS; Cancer Pharmacokinetics and Pharmacodynamics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Zhang W; Department of Computer Science, University of Central Florida, Orlando, Florida, USA., Teer JK; Department of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Teng M; Department of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Yoder SJ; Molecular Genomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Siegel EM; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Shah BD; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Nishihori T; Department of Blood & Marrow Transplant and Cellular Therapies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Hazlehurst LA; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA., Lynch CC; Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Landgren O; Division of Myeloma, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA., Hampton O; Aster Insights, Tampa, FL, USA., Gatenby RA; Departments of Radiology and Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Sullivan DM; Department of Blood & Marrow Transplant and Cellular Therapies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Brayer JB; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Dalton WS; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Cleveland JL; Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Alsina M; Department of Blood & Marrow Transplant and Cellular Therapies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Baz R; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Shain KH; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.; Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Silva AS; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Source: Research square [Res Sq] 2025 Apr 15. Date of Electronic Publication: 2025 Apr 15.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Renatino+Canevarolo+R%22">Renatino Canevarolo R</searchLink>; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sudalagunta+PR%22">Sudalagunta PR</searchLink>; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Meads+MB%22">Meads MB</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Silva+M%22">Silva M</searchLink>; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Malignant Hematology, H. 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Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Siegel+EM%22">Siegel EM</searchLink>; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Shah+BD%22">Shah BD</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Nishihori+T%22">Nishihori T</searchLink>; Department of Blood & Marrow Transplant and Cellular Therapies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hazlehurst+LA%22">Hazlehurst LA</searchLink>; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Lynch+CC%22">Lynch CC</searchLink>; Department of Tumor Microenvironment and Metastasis, H. 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Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Dalton+WS%22">Dalton WS</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cleveland+JL%22">Cleveland JL</searchLink>; Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Alsina+M%22">Alsina M</searchLink>; Department of Blood & Marrow Transplant and Cellular Therapies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Baz+R%22">Baz R</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Shain+KH%22">Shain KH</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.; Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Silva+AS%22">Silva AS</searchLink>; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
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